W. R. Grace Co.-conn.

The Medical College of Pennsylvania

Rhode Island Hospital

Allegheny University of the Health Sciences

The Medical College of Pa

Panacea Pharmaceuticals, Inc.

Alan H Deutch

George Paul Tuszynski

Victor A David

Jack Raymond Wands

Suzanne M De La Monte

Hossein A Ghanbari

Julia B Wolf

Goerge Tuszynski

The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.

Diagnosis and treatment of malignant neoplasms

Compounds and compositions comprising fragments and synthetic analogs of human thrombospondin are provided together with methods for their use as thrombospondin-like agents.

Peptide fragments and analogs of thrombospondin

Piptide fragments and analogs of thrombospondin

An expression method for enhanced recombinant production of a desired protein due to the presence of lactation-signals is provided which comprises cells transformed with a DNA sequence having the desired protein coding sequence under the control of a bovine prolactin promoter and a bovine prolactin distal enhancer sequence. A preferred embodiment uses growth hormone sequences as the desired protein coding sequences. In this embodiment, feed-efficiency of milk-producing animals is improved.

Enhanced gene expression in response to lactation signals

Use of peptide analogs of thrombospondin for the inhibition of

Peptide fragments and analogs of thrombospondin and methods of use

Neutral protease genes from Vibrio proteolyticus or Bacillus can be cloned and expressed in gram-negative microorganisms, such as E. coli or Serratia. The functional neutral protease enzyme is expressed.

Molecular cloning and expression of neutral protease genes

Molecular cloning and expression of a vibrio proteolyticus neutral

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Columbia, MD, United States of America

Alan H Deutch