G.d. Searle & Company

Pharmacia Corporation

Alan G Porter

Leslie D Bell

Keith G McCullagh

Paul G Boseley

John Robert Adair

John C Smith

Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities. Also described is a peptide linker segment comprising a mouse IgG gamma &ldquo;hinge&rdquo; in which the four cysteines of the &ldquo;hinge&rdquo; have been converted to serines.

Peptide linkers for covalent linking polypeptide cell modulators

Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities.

Covalently linked polypeptide cell modulators such as

Covalently linked polypeptide cell modulators

A composition of matter comprising a polypeptide of the formula:

Structure and properties of modified interferons

Human interferons containing novel cysteine substitutions and disulfide bonds are disclosed. The amino acid sequence of a first interferon is combined with the cysteine and/or disulfide pattern of a second interferon resulting in a molecule with hybrid properties.

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High Wycombe, United Kingdom

Alan G Porter