Walter and Eliza Hall Institute of Medical Research

Seattle Biomedical Research Institute

Expres2ion Biotechnologies

Alan E Cowman

Lin Chen

Alexander Gerd Maier

Tony Triglia

Stefan H I Kappe

Ann-Kristin Mueller

Kai-Uwe C Matuschewski

David J Kemp

Willem Adriaan De Jongh

Robin Fredric Anders

Mehdi Labaied

Jacob Baum

Ahmed Sayed Ibrahim Aly

Kelley Van Buskirk

Thomas Dan Jorgensen

Vladyslav Soroka

James Beeson

Graham V Brown

Robert B Saint

Albert E Bianco

Graham F Mitchell

Kristina E M Persson

Ross Coppel

Julie Healer

Teit Max Moscote Sogaard

Jonathan S Richards

Sash Lopaticki

The present description relates to malaria vaccines comprising(Pf) polypeptide complexes and methods of producing the same. The Pf polypeptides in complexes or in a partially complexed arrangement may comprise two or more of the following polypeptides: PfRipr, PfCyrPa and PfRh5.cells and expression vectors are also described.

Malaria vaccine and methods for producing same

The present invention relates to recombinant fragments ofpolypeptides and polynucleotides encoding same. The invention further relates to compositions comprising the recombinant fragments ofpolypeptides and their use in the treatment and prevention of malaria.

Treatment and prevention of malaria

This invention relates to an immunogenic molecule comprising a contiguous amino acid sequence of an invasion ligand of a strain of, the invasion ligand capable of binding to an erythrocyte receptor, the receptor function being resistant to trypsin and neuraminidase and chymotrypsin, wherein when administered to a subject the molecule is capable of inducing an immune response to the strain. The invention further relates to compositions and methods for the treatment of diseases such as malaria.

Methods and compositions for treating and preventing malaria using an invasion ligand directed to a protease-resistant receptor

The present invention relates to polypeptides fromand polynucleotides encoding the polypeptides. The invention further relates to compositions comprising the polypeptides and their use in the treatment and prevention of malaria.

The present invention provides compositions and methods useful in the treatment or prevention of a condition caused by or associated with infection by, such as malaria. The compositions include various antigens of, both alone and in combination. The invention further includes fragments of the antigens.

Methods and compositions for treating and preventing malaria (2)

Method for inoculating a vertebrate host against malaria, by administering to the host a liveorganism that is genetically engineered to disrupt a liver-stage-specific gene function.

Live genetically attenuated malaria vaccine

DNA molecules comprising polynucleotide sequences substantially corresponding to all or a portion of the base sequence coding for an antigen of Plasmodium falciparum selected from the group consisting of the RESA antigen, the FIRA antigen, and other antigens of P. falciparum cross-reactive therewith. Such DNA molecules are capable of being expressed as polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of the RESA or FIRA antigens of P. falciparum. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of the RESA or FIRA antigens of P. falciparum.

The RESA and FIRA antigens of plasmodium falciparum

Growing community of inventors

North Carlton, Australia

Alan E Cowman