Alastin Skincare, Inc.

University of California

Other

Allergan, Inc.

Alan David Widgerow

John Anthony Garruto

Derek Banyard

Jered Haun

Hugo Salas

Ahmed Zobi

David Duarte

Justin Stovner

Xiaolong Qiu

Michael Klopfer

John A Garruto

Lohrasb H Sayadi

Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.

Compositions and methods for invasive and non-invasive procedural skincare

Compositions and methods for improving bruising, stimulating elastin and/or collagen production, stimulating intrinsic hyaluronic acid production, stimulating adipogenesis, reducing inflammation, or combinations thereof are provided herein. Compositions and methods described herein may be used following a cosmetic procedure.

Compositions and methods for improving bruising and rejuvenating skin

Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).

Method and device for processing tissues and cells

Provided herein are liposomal compositions for improved delivery and penetration into the skin. Liposomal compositions as provided herein comprise one more peptides. Also provided herein are compositions and methods for targeting dermal white adipose tissue to improve fat reduction and anti-aging effects. Compositions and methods for targeting dermal white adipose tissue may comprise administering a composition comprising liposomes.

Liposomal compositions and methods of use

The invention provides an apparatus for the generation and administration of a micro-nanobubble solution to a tissue, a method for the treatment of a tissue with a solution of micro-nanobubbles, and a kit for the treatment of tissue with micro-nanobubbles.

Micro/nanobubble solutions for tissue preservation and generation thereof

Compositions and methods for amelioration of skin laxity and body contour are provided. Provided herein are compositions comprising a combination of peptides.

Methods for fat reduction or elimination of lipid droplets

Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180&#xb0; on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).

Beneficial topical compositions for treating scar or aging skin are provided. In one embodiment, the compositions includeand a phenol derived from olives, such as oleuropein. The composition may be used in the treatment of scars formed during surgery. The composition may also be used cosmeceutically in the treatment of aged skin, and may include phosphatidylserine, vitamins, and other beneficial anti-aging ingredients.

Methods for treating scars and aging skin

Peptide compositions and methods for ameliorating skin laxity and body contour

A method of processing a lipoaspirate sample includes mechanically processing the lipoaspirate sample to generate nanofat. The nanofat is then input into a microfluidic device comprising a plurality of serially arranged stages comprising one or more microfluidic channels having a plurality of expansion and constriction regions extending along the length of the one or more microfluidic channels, wherein each subsequent stage of the plurality has an increasing number of microfluidic channels of decreasing dimensions. The nanofat is flowed through the plurality of serially arranged stages in a plurality of cycles to generate sheared nanofat. The sheared nanofat is then collected after flowing through the plurality of serially arranged stages. The sheared nanofat may then be injected and/or applied to the subject. In an alternative embodiment, filtered or mechanically processed lipoaspirate may be run through the microfluidic device.

Growing community of inventors

Irvine, CA, United States of America

Alan David Widgerow