Icagen, Inc.

Icafen, Inc.

Alan David Wickenden

Michael F Gross

Timothy James Jegla

Grant Andrew McNaughton-Smith

Yi Liu

Serge Beaudoin

Aimee Dolores Reed

Gregory Cooksey Rigdon

Anrou Zou

The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.

Antibodies to human Elk, a voltage-gated potassium channel subunit

The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for screening for activators and inhibitors of the Slo family potassium channels comprising BK beta subunits.

BK beta subunits of Slo family potassium channels

The invention provides isolated nucleic acid and amino sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo family potassium channels comprising BK beta subunits.

Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.

Benzanilides as potassium channel openers

Human Elk, a voltage-gated potassium channel subunit

Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.

Potassium channel inhibitors

Beta subunits of Slo family potassium channels

Human elk a voltage-gated potassium channel subunit

The present invention relates to a novel method of treating of pain, using compounds that modulate KCNQ potassium channels and currents.

Growing community of inventors

Cary, NC, United States of America

Alan David Wickenden