The Dow Chemical Company

Dow Global Technolgoies LLC

Eastman-kodak Company

Sorbent Therapeutics, Inc.

Kemeta, LLC

Alan D Strickland

Jaime Simon

R Keith Frank

David A Wilson

Paul E Cranley

Druce K Crump

Alan K Schrock

James A McIntyre

Theodore E Miller, Jr

Kenneth McMillan

Charles J McDonald

James David Tate

Eric R Brown

Jeffrey Allen

Venkiteswaran Subramanian

Daniel J Macey

Kristine L Danowski

Bettina M Rosner

Larry Sun

Ted E Miller

Michael J Bartels

Scott P Crane

Brian D Burkholder

Dana W Simon

The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.

In vivo use of water absorbent polymers

Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics. 

Enzyme-based system and sensor for measuring acetone

This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharmaceuticals to the site of osteomyelitis.

Treatment of osteomyelitis with radiopharmaceuticals

The present invention concerns the use of a radioiodinated phenolic compound of the formulawherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R, Rand Rare independently hydrogen, C-Calkyl, or a carboxyl group, and I* isI,I orI, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.

Radioiodinated sulfonated phenols and process therefore

A medical breath component analyzer which maintains a data-base profile of a patient over time. The apparatus may be used chronically by a patient so that a baseline status for that patient may be determined. Acute variations from the baseline are identified as clinically significant. The acquired data can be reported to the patient using the device at home and transmitted electronically to a physician or health care provider. The method and apparatus helps a patient modify health related behaviors, particularly weight loss for diabetic patients. A breath component and information on the psychological or emotional state of the patient are correlated, and information is provided to the patient based on the correlation between the breath component and the patient's emotional state. Other physiologic parameter may also be measured, such as a blood component, temperature, cardiovascular condition or pulse rate, a urine component, a physical activity sensor, weight, or body fat composition sensor. The parameters and the information on the patient's emotional state may be correlated through a computer system. Correlation may comprise selecting a response likely to re-enforce positive behavioral change in the patient. Preferably, remote sources of information may also be accessed, as, for example, through a communications connection or the Internet. Information may be provided directly from the apparatus, or by contact through a physician, health-care provider or support group.

Personal computer breath analyzer for health-related behavior modification and method

Radioiodinated sulfonated phenols for the study of renal function

A process for preparing polyamino monosuccinic acids, salts or chelates thereof by (a) reacting a maleic or fumaric acid ester or mixtures thereof with a polyamino compound in a primary alcohol as a solvent, (b) hydrolyzing the product obtained in step (a), and (c) separating the primary alcohol. The use of a primary alcohol as the solvent results in a markedly purer polyamino monosuccinic acid product and simpler reaction conditions than when the solvent is a secondary or tertiary alcohol.

Process for the preparation of polyamino succinic acids and derivatives thereof

The present invention concerns the use of a radioiodinated phenolic compound of the formula

Radioiodinated sulfonated phenols for brachytherapy

Chelants represented by Formula 1b: ##STR1## are determined to be biodegradable when Distance A is from about 3.8.times.10.sup.-10 to about 4.6.times.10.sup.-10 m, Distance B is from about 5.1.times.10.sup.-10 to about 5.9.times.10.sup.-10 m, and Distance C is from about 4.3 to about 6.7.times.10.sup.-10 m). Compounds meeting these criteria are referred to as compounds of Formula 2. In addition to methods of analysis and computer systems therefor, the invention includes a method of chelating a metal ion to form a chelate and biodegrading the chelate comprising step (a) contacting the metal ion with at least one compound of Formula 2 to form a chelate and (b) contacting the resultant chelate or chelant with microbes of the type specified in ASTM 2667-89, ISO 5815 or effective enzymes thereof under conditions and for a time sufficient for biodegradation wherein either (i) the chelate formed in step (a) is formed in a process of removing deposits, scale, or rust; cleaning or washing; controlling metal initiated or catalyzed oxidation or deterioration including spoilage, discoloration, or rancidification; textile treatment; paper making; stabilization of polymers or phosphates; or petroleum drilling, production or recovery; or (ii) the chelate formed in step (a) is before step (b) used as a redox catalyst, in a process of photographic bleaching, bleach-fixing or developing; in electroless deposition or plating; in removing acid or oxide gases including H.sub.2 S, NO.sub.X, SO.sub.X, CO and CO.sub.2 ; or in providing agricultural nutrients.

Determining biodegradability of aspartic acid derivatives, degradable

An analytical process for determining the biodegradability of chelants containing a double carboxyl-containing moiety of specified formula, based on the atomic distances between the carboxyl moieties, is disclosed. According to this process the biodegradability of a chelant can be rapidly determined by determining whether the distance between the carboxyl carbon atoms ('Distance A') falls within the range of from about 3.81.times.10.sup.-10 m to about 3.86.times.10.sup.-10 m; the distance between the carboxyl double bonded oxygen atoms ('Distance B') falls within the range from about 5.13.times.10.sup.-10 to about 5.52.times.10.sup.-10 m; and the distance between the carboxyl hydroxy oxygen atoms ('Distance C') falls within a range of from about 5.28.times.10.sup.- m to about 6.09.times.10.sup.-10 m; and whether the lowest unoccupied molecular orbital (LUMO) is on at least one carboxyl carbon atom of the moiety. If all of the above criteria are met, the compound is predicted to be biodegradable.

Analytical process to determine biodegradability of chelants containing

Chelants represented by Formula 1b: ##STR1## are determined to be biodegradable when Distance A is from about 3.8.times.10.sup.-10 to about 4.6.times.10.sup.-10 m, Distance B is from about 5.1.times.10.sup.-10 to about 5.9.times.10.sup.-10 m, and Distance C is from about 4.3 to about 6.7.times.10.sup.-10 m). Compounds meeting these criteria are referred to as compounds of Formula 2. In addition to methods of analysis and computer systems therefor, the invention includes a method of chelating a metal ion to form a chelate and biodegrading the chelate comprising step (a) contacting the metal ion with at least one compound of Formula 2 to form a chelate and (b) contacting the resultant chelate or chelant with microbes of the type specified in ASTM 2667-89, ISO 5815 or effective enzymes thereof under conditions and for a time sufficient for biodegradation wherein either (i) the chelate formed in step (a) is formed in a process of removing deposits, scale, or rust; cleaning or washing; controlling metal initiated or catalyzed oxidation or deterioration including spoilage, discoloration, or rancidification; textile treatment; paper making; stabilization of polymers or phosphates; or petroleum drilling, production or recovery; or (ii) the chelate formed in step (a) is before step (b) used as a redox catalyst, in a process of photographic bleaching, bleach-fixing or developing; in electroless deposition or plating; in removing acid or oxide gases including H.sub.2 S, NO.sub.x, SO.sub.x, CO and CO.sub.2 ; or in providing agricultural nutrients.

Method of chelating a metal ion to form a chelate and biodegrading the

Chelants represented by Formula 1b: ##STR1## are determined to be biodegradable when Distance A is from about 3.8.times.10.sup.-10 to about 4.6.times.10.sup.-10 m, Distance B is from about 5.1.times.10.sup.-10 to about 5.9.times.10.sup.-10 m, and Distance C is from about 4.3 to about 6.7.times.10.sup.-10 m.

Determining the biodegradability of iminodiacetic acid derivatives

Polyamino monosuccinic acid chelants are disclosed which have been found to be applicable in photographic processes. The polyamino monosuccinic acids can be used in a method of bleaching or bleach-fixing a silver halide photographic material comprising contacting the photographic material with a bleaching solution containing a metal complex of a polyamino monosuccinic acid as a bleaching agent.

Growing community of inventors

Lake Jackson, TX, United States of America

Alan D Strickland