Viacyte, Inc.

Cythera, Inc.

University of Georgia Research Foundation, Inc.

Alan D Agulnick

Kevin Allen D'Amour

Emmanuel Edward Baetge

Susan Eliazer

Olivia Kelly

Evert Kroon

Kevin Allen D'amour

Allan J Robins

Chad Green

Thomas C Schulz

Yuki Ohi

Laura A Martinson

E Edward Baetge

Xiaojie Yu

Anne Bang

Anindita Bhoumik

Eugene Brandon

Kevin A D'amour

Michael J Scott

Stephen Dalton

Karen Jones

Susan Eliazar

Thomas Schultz

Allan Sheppard

Ed Baetge

Kevin D' Amour

Kevin D'amour

Eugene P Brandon

Allan Robins

Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as induced pluripotent stem (iPS) cells, and methods for producing and using such cell culture compositions.

Cell encapsulation device comprising a pancreatic progenitor cell population

Disclosed herein are universal donor stem cells and cells derived therefrom and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming allogeneic immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor cells disclosed herein are pancreatic endoderm cells that do not express one or more MHC-Class I cell-surface proteins and whose expression of at least one NK activating ligand is disrupted or inhibited.

Universal donor cells and related methods

Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.

PDX1 positive foregut endoderm cells and methods of production

This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.

Methods of making human primitive ectoderm cells

A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.

Cryopreserved endocrine cells that express chromogranin A

Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of dorsal and/or ventral PDX1-positive foregut endoderm cells, are also disclosed.

Methods of producing human foregut endoderm cells expressing PDX1 from human definitive endoderm

Disclosed herein are methods for cryopreserving, hibernation and room temperature storage of PEC aggregates, implantable semipermeable devices and the VC combination product.

Cryopreservation of encapsulated pancreatic endoderm cells

Anterior endoderm cells and methods of production

Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.

Definitive endoderm

University donor cells and related methods

Methods for producing hormone secreting cells in a subject

Cell compositions derived from dedifferentiated reprogrammed cells

Growing community of inventors

San Marcos, CA, United States of America

Alan D Agulnick