American Home Products Corporation

Wyeth

Alan Corbin

Frederick J Bex

Michael S Dey

John P Yardley

This invention provides a method of treating estrogen receptor positive carcinoma in a mammal in need thereof which comprises administering an antineoplastic amount of 17(&#x3b1;-dihydroequilin or a mammalian metabolic conjugate thereof orally, parenterally, transdermally, topically, rectally, intravaginally, intranasally, or intrabronchially. As such, the compounds of this invention are useful in treating estrogen receptor positive carcinomas such as carcinomas of the breast, uterus, ovary, fallopian tube, cervix, vagina, liver, pituitary, central nervous system, hypothalamus, bone, skin, kidney, urethra, prostate, and the like.

Method of treating estrogen receptor positive carcinoma with 17 &#x3b1;-dihydroequilin

This invention provides a method of treating estrogen receptor positive carcinoma in a mammal in need thereof which comprises administering an antineoplastic amount of 17&agr;-dihydroequilin or a mammalian metabolic conjugate thereof orally, parenterally, transdermally, topically, rectally, intravaginally, intranasally, or intrabronchially. As such, the compounds of this invention are useful in treating estrogen receptor positive carcinomas such as carcinomas of the breast, uterus, ovary, fallopian tube, cervix, vagina, liver, pituitary, central nervous system, hypothalamus, bone, skin, kidney, urethra, prostate, and the like.

Method of treating estrogen receptor positive carcinoma with 17 &agr;-dihydroequilin

The use of LRH and LRH agonists as contraceptives in the planetal mammal is disclosed.

Use of LRH and LRH agonists

The invention embraces the novel nonapeptide L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-alanyl-L-leucyl -L-arginyl-L-prolinethylamide, intermediates for its production and its use as a claudogenic-interceptive agent.

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Delaware, PA, United States of America

Alan Corbin