Fisons Ltd.

Astra Pharmaceuticals Limited

Astrazeneca Ab

Astra Zeneca U.k. Limited

Alan C Tinker

Peter Richard Hamley

Thomas McInally

Francis Ince

Austen Pimm

John Dixon

Andrew J Baxter

James Russell Matz

Kenneth J Gould

Haydn Beaton

James E MacDonald

There are provided novel compounds of formula (I)

Aminopyrimidine derivatives, processes for their preparation, compositions containing them and their use as pharmaceuticals

The invention relates to the co-administration of an inhibitor of induced nitric oxide synthase and an inhibitor of cyclooxygenase-2 for the treatment of inflammation and inflammatory disorders.

Pharmaceutical combination comprising a COX-2 inhibitor and a iNOS inhibitor

Amino-spiro-quinazoline compounds

Spiro-piperidine derivatives as inhibitors of nitric oxide synthase

Compounds

Aminoisoquinolines and aminotheinopyridine derivatives and their use as

Combination

Pharmaceutically active compounds

There are provided compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds.

There are provided paraethylamine phenol compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds.

Para ethyl amino phenol pharmaceutical compounds

There are described compounds of formula I, ##STR1## in which R.sub.1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted,

Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines

There are provided pharmaceutical compounds useful in treating hypertension, heart diseases and renal failure. These compounds are 4-hydroxy phenethylamines wherein the 3 position on the phenyl nucleus is occupied by either an amino, amide, carbamyl, urea sulfonamide, substituted alkyl or fluorine atom, and the amine group is further linked to another phenyl radical through an alkylene radical which may contain nitrogen, oxygen, sulfur or cyclic hydrocarbon radicals as intervening groups.

There are described compounds of formula I, ##STR1## in which R.sub.1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted by one or more of the groups halogen, nitro, --CN, --OR.sub.9, --S(O).sub.p R.sub.9, or alkyl C1 to 6 optionally substituted by halogen,

Growing community of inventors

Loughborough, United Kingdom

Alan C Tinker