Pfizer Corporation

Alan C Curtiss

Gautam R Ranade

Jeelin Lo

David K Longhenry

Julius Praglin

Bruce H Sielaff

James E McKie, Jr

Charles B Bidwell

Improved means for constraining a rumen drug delivery device in a rolled configuration, said means comprising a laminate, which may be perforated, comprising a water-permeable material having a low friction surface in the presence of water, said material being bonded by means of a water-dispersible pressure sensitive adhesive to a repulpable tape, said tape having said water-dispersible pressure sensitive adhesive on both its surfaces; a laminate comprising a flexible, water-permeable polymeric material bonded between the low friction surface material and the repulpable tape; and devices constrained by said means.

Means for constraining a rumen drug delivery device in a rolled

A method for enhancing the unrolling of a rolled active agent-containing laminate device in an aqueous use environment which comprises coating one side of the device with an elastomer prior to constraining it in a rolled configuration; and the devices so treated.

Rolled matrix device having enhanced ability to unroll and method for

The method and apparatus for testing the susceptibility of bacteria to antibiotics described in the U.S. Pat. No. 3,832,532 and related patents are adapted for identifying various strains of bacteria by determining the light scatter indices (LSI) for a special group of antimicrobials, which have particularly significant characteristics with respect to identifying the strains of microorganisms, and analyzing them by a computer method, such as a quadratic discriminant function statistical technique, to identify the microorganisms to which the antimicrobials are applied. It has been found that 14 antimicrobial agents provide an extremely reliable identification and it is believed that the identifying group of agents could be reduced without sacrificing too much reliability. The agents preferably should be those which are not in common therapeutic use to avoid errors resulting from strains which have become immune to various therapeutically-utilized antibiotic agents. A presently defined group of such agents includes approximately 36 members (later described herein of which a number can be selected for reliable identification purposes by statistical techniques).

Method and apparatus for identifying microorganisms

A number of discs are simultaneously dispensed into a culture dish from a dispenser having an array of self-contained dispensers locked in apertured sockets on a base frame. The individual dispensers are simultaneously operated by an actuating plate which engages actuating pins on each of them. The height of the dispenser above the culture dish is adjustable by cam and follower engagement of the base plate within a height-adjusting ring. Indicia and yieldable detents are provided for indexing the height of the base plate. The individual dispensers each include a chute-incorporating body, cover, slide plate, spring and tubular cartridge. The open tops of the chutes provide visual confirmation that a disc has been discharged from each of the dispensers. Weights and spring clips in the cartridges push the discs successively into firm contact with the dispensing slide plates for dependably delivering them into the dispenser chutes.

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Old Lyme, CT, United States of America

Alan C Curtiss