Sloan-kettering Institute for Cancer Research

Varian Medical Systems, Inc.

Albert Einstein College of Medicine

Montefiore Medical Center

Alan A Alfieri

Chandan Guha

Sang H Kim

Jae H Kim

Robert M Sutherland

Zvi Fuks

Subhrajit Saha

Payel Bhanja

Charles W Young

Jayanta Roy-Chowdury

Methods are provided for treating, mitigating or protecting from radiation-induced injury using bone marrow stromal cells expanded in culture, adipose-tissue derived non-adherent stromal cells, or the culture supernatant thereof.

Stromal cell therapy in treatment of radiation injury

Disclosed are methods of obtaining an expanded population of mammalian ex vivo cells for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested or left at the engraftment site. Methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury are also described.

Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation

This invention provides methods for inhibiting the proliferation of brain or hepatic metastases, in vivo, by contacting the cells with lonidamine and radiation.

Methods for inhibiting the proliferation of brain and hepatic metastases

This invention provides a method of killing sarcoma cells in a patient by administering to the patient an effective amount of fludarabine phosphate effective to inhibit the repair of potentially lethal damage to the sarcoma cells and exposing the patient to an effective amount of ionizing radiation, effective to kill the sarcoma tumor cells in the patient.

Method of killing sarcoma cells using fludarabine phosphate and ionizing

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Garden City, NY, United States of America

Alan A Alfieri