Rhone-poulenc Sante

Rhone-poulenc Rorer S.a.

Alain Truchon

Jean-Francois Peyronel

Michel Tabart

Claude Moutonnier

Jean-Luc Malleron

Daniel Achard

Claude Gueremy

Serge Mignani

Marie-Christine Dubroeucq

Serge Grisoni

Marie-Therese Comte

Stephen Hanessian

Patrick Mailliet

Alain Commercedillaon

Fabienne Sounigo-Thompson

Alain Le Brun

Jean-Francedillaois Peyronel

Martine Zucco

Marie-Iherese Comte

4,9-ethano-benzo(F)isoindole derivatives as farnesyl transferase

Derivatives of perhydroisoindole and preparation thereof

Thiopyranopyrrole derivatives

Perhydroisoindole derivatives and pharmaceutical compositions containing

This invention relates to compounds of formula: ##STR1## in which R.sub.1 denotes

Serotonin antagonists, their preparation and medications containing them

New isoindolone derivatives of general formula (I) are ##STR1## disclosed in which the radicals R represent hydrogen atoms or, together, form a bond, the symbol R' represents a hydrogen atom or a readily removable radical and the symbols R' are identical and represent phenyl radicals which can be substituted with a halogen atom or a methyl radical at the ortho or meta position, in the (3aR, 7aR) form or in the form of a mixture of the (3aRS, 7aRS) forms, as well as their salts. These derivatives are useful as intermediates for the preparation of therapeutically active products.

Isoindolone derivatives

This invention relates to isoindolone derivatives of general formula (I) in which the radicals R are hydrogen atoms or together form a bond, the symbols R' are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3, X is an oxygen or sulphur atom or a radical N--R.sub.3, R.sub.3 being H, optionally substituted alkyl or dialkylamino, R.sub.1 is optionally substituted phenyl or cyclohexadienyl, naphthyl or a heterocycle and R.sub.2 is H, halogen, OH, alkyl, amionoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, carboxyl, optionally substituted alkoxycarbonyl, benzyloxycarbonyl, amino or acylamino, in their (3aR,7aR) forms or in the (3aRS,7aRS) form or their mixtures, and if appropriate their salts where such exist, and their preparation. The new derivatives according to the invention are particularly valuable as antagonists of substance P. ##STR1##

Isoindolone derivatives, their preparation and the pharmaceutical

This invention relates to a compound of the formula: ##STR1## in which R.sub.1 represents

Derivatives of (AZA) naphthalensultam, their preparation and

This invention relates to a compound ##STR1## in which R.sub.1 represents

Derivatives of (AZA)naphthalenesultam, their preparation and

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Lyons, France

Alain Truchon