Georgetown University

The United States of America As Represented by the Department of Health

Alain Thierry

Anatoly Dritschilo

Aquilur Rahman

The present invention is directed to a liposomal preparation which is based on specific lipid components. The liposomal compounds are also combined with nucleic acids, forming nucleic acid-liposomal compounds. These compounds are useful in drug delivery, where specific therapeutic nucleic acids are used in the liposomes. The specific lipid components of the present invention provide a highly efficient and stable delivery system for nucleic acids. Consequently, the liposomal preparations are suitable for use in gene therapy.

Method for the liposomal delivery of nucleic acids

An improved method for encapsulating high molecular weight nucleic acids in liposomes, which provides for high nucleic acid entrapment efficiencies, is provided. The resulting compositions provide enhanced in vitro and in vivo transfection and are useful, for example, in producing cell lines expressing a desired nucleic acid sequence.

Liposomally encapsulated nucleic acids having high entrapment

A liposome, which contains an oligodeoxynucleotide or an analog thereof.

Method of making liposomal oligodeoxynucleotide compositions

A method of preparing a liposomal anthracycline glycoside composition, which entails forming cardiolipin-containing liposomes by drying a lipid mixture containing cardiolipin, and then introducing an aqueous solution, and mixing the cardiolipin-containing liposomes with a solution of anthracycline glycoside.

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Alain Thierry