Coletica

Bioetica, S.a.

Other

Societe Anonyme, Bioetica

Bioetica

Alain Roger Huc

Rene Gimeno

Eric Perrier

Chantal Buffevant

Nabil Abdul Malak

Roland Allard

Daniel Herbage

Daniele Antoni

Marie-Christine Levy

Philippe Menasche

Marie-Christine Andry

Val&eacute;rie Andre

Valerie Andre

Isabelle Orly

Jacques Bejui

Jean Graille

Michel Pina

Coralie Roussel

Herve Petite

Danielle Antoni

Pierre Devictor

Eric Jean-Luc Perrier

Nabil Abdul-Malak

Jean Fourcart

Patrick Le Pivert

Pierre DeVictor

The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising at least one porous collagen layer covered on at least one side with a collagen membrane component selected from the group consisting of a collagen membrane prepared by compression of a collagen sponge at a pressure of at least about 50 bar and of a collagen membrane comprising a collagen film prepared by drying a collagen gel separately from the porous collagen layer, thereby providing a reliable method for finding new potentially active substances.

Support with collagen base for tissue engineering and manufacture of biomaterials

A composite product is disclosed as a collagen support comprising at least one porous collagen layer covered on at least one side with an essentially compact collagen membrane consisting either of a collagen film prepared by drying a collagen gel, preferably in air or a gaseous fluid, or of a very highly compressed collagen sponge. At least one of the two layers, i.e. the porous layer and the essentially compact membrane, may comprise normal, genetically modified or malignant living cells originating particularly from young or elderly subjects. This composite product is used as a collagen support for the manufacture of artificial skin intended especially for performing in vitro tests on the efficacy of potentially active substances or for reconstructing damaged areas of skin in vivo.

Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained

Cosmetic and pharmaceutical compositions comprising amphiphilic or hydrolipidic complexes of plant proteins modified with fatty chains are presented. The modified proteins are obtained from the reaction carried out at a temperature between ambient temperature and 80&deg; C. with plant proteins having an average molecular mass is greater than or equal to 10,000 Daltons and one or more fatty chains whose carbon atom number is between 4 and 30, selected from fatty acid anhydrides and fatty acid halides, with the exclusion of undecylenic acid.

Amphiphilic complexes, method for their preparation and compositions containing them

The invention relates to a collagen product containing collagen of marine origin with a low odor. The collagen product includes one or more collagens or derivatives thereof, including hydrolyzates, with a low odor, at least part of the collagen or the derivatives being of marine origin and having been subjected to a deodorization treatment, particularly with an oxidizing substance such as a sulfite, hydrogen peroxide or ozone, at any stage of the manufacture of the collagen product. The invention also makes it possible to improve the mechanical properties and to use this low-odor collagen product in cosmetic or pharmaceutical products.

Collagen product containing collagen of marine origin with a low odor and preferably with improved mechanical properties, and its use in the form of cosmetic or pharmaceutical compositions or products

Use of collagen of aquatic origin for the production of supports for tissue engineering is disclosed. The collagen may be obtained from fish skin, preferably in its native form. Novel tissue engineering supports with a low risk of contamination are produced.

Use of collagen of aquatic origin for the production of supports for tissue engineering, and supports and biomaterials obtained

A method for producing nanocapsules with cross-linked protein-based walls, comprising preparing emulsions of said proteins and crosslinking these with a crosslinking agent having reactive groups which react with the reactive groups of said proteins, particularly acylatable groups, to cause an interfaced crosslinking reaction between the proteins and the crosslinking agent, and thereby form capsules with walls based on the proteins crosslinked by the crosslinking agent. A fine emulsion of said proteins is prepared by adjusting the surface tension of the various liquid phases. Biocompatible and biodegradable nanocapsules having improved controlled release are thereby obtained.

Method for producing nanocapsules with crosslinked protein-based walls nanocapsules thereby obtained and cosmetic, pharmaceutical and food compositions using same

The invention relates to new lipophilic hydroxylated acids wherein said lipophilic hydroxylated acid comprises a hydrophobic hydrocarbon chain having from 7 to 30 carbon atoms grafted onto the hydroxyl functional group and/or the acid functional group of the lipophilic hydroxylated acid via a covalent bond chosen from the group consisting of an ester bond on the hydroxyl functional group, an anhydride bond on the acid functional group and an amide bond on the acid functional group, provided that, in the case of an amide bond, this hydrophobic hydrocarbon chain consists of an alkyl radical having from 10 to 30 carbon atoms resulting from a monoamine, or a combination of these bonds. These new derivatives are useful as active ingredient of cosmetic or pharmaceutical compositions and as emulsifying agents.

Lipophilic hydroxylated acid, its use in cosmetics and pharmacy, and its

A collagen-based composition including microcapsules of atelocollagen or of a mixture of atelocollagen and a polysaccharide, particularly glycosaminoglycan, suspended in a viscous biocompatible carrier solution. Together, the microcapsules and the viscous carrier solution preferably have a viscosity such that the composition may be injected, in particular as a continuous thread from a needle. Said composition is readily injectable and may be used as a soft or bony tissues filling material for, or as a system for the controlled delivery and release of biologically, cosmetically or pharmaceutically active substances.

Injectable compositions containing collagen microcapsules

The invention relates to the use of collagen as solid binding substrate for a sensor called ligand or refining agent, capable of reacting specifically with an element to be detected in a biological medium, to form a specific complex. Preferably, the solid substrate comprises atelocollagen or a mixture of atelocollagen and of polyholoside. The invention thus makes it possible to provide a biological reactant of high specificity and of which the constituents are of natural origin. It can be used easily and quickly.

Use of a collagen as solid binding substrate for a ligand capable of

The invention relates to microcapsules with a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, and to processes for the manufacture of the said microcapsules. According to the invention, the microcapsules comprise a mixed wall of crosslinked atelocollagen and polyholosides, for example glycosaminoglycans, the proportion of polyholosides, for example glycosaminoglycans, relative to the atelocollagen preferably being between 18 and 50% by weight. These microcapsules can be manufactured either by a process involving interfacial crosslinking or by the extrusion of a laminar flow which is broken up by vibrations into individual droplets, which fall into a crosslinking bath. These microcapsules are biocompatible by virtue of the presence of atelocollagen, which has most of the advantageous properties of collagen, namely a very low antigenicity and a perfect biodegradability. The are therefore particularly suitable for the manufacture of cosmetic, pharmaceutical or food compositions.

Process of manufacture of biodegradable microcapsules having walls

Suturable, biocompatible, control-resorbing membranes are disclosed for use in guided tissue regeneration, comprising a cross-linked collagen material either obtained by crosslinking a starting collagen material in the coagulated state produced by coagulation of a collagen material gel with a coagulating agent or obtained by crosslinking of a sponge of a collagen material on which a collagen material gel has been poured before performing the crosslinking.

Collagen crosslinked with a crosslinking agent for the manufacture of a

Microcapsules having a combined atelocollagen/polyholoside wall

The invention relates to a polyose/fatty acid complex product. This complex product is the reaction product of at least one polyose with at least one fatty acid, in particular in the form of a halide or the anhydride. The fatty acid can be saturated or unsaturated and can comprise from 8 to 28 carbon atoms. This complex product has a high moisturizing capacity and, surprisingly, an emulsifying capacity and can be used to prepare valuable cosmetic or pharmaceutical compositions.

Growing community of inventors

Sainte Foy Les Lyon, France

Alain Roger Huc