Other

Forest Laboratories Holdings Limited

Novexel

Pfizer Ireland Pharmaceuticals

Alain Priour

Alain Bonnet

Mahendra G Dedhiya

Alexandre Giuliani

Valérie Ravaux

Véronique Ducandas

Sisir Bhattacharya

Peter Spargo

Alain Mazurie

Gilles Oddon

The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) thereof. The present invention relates to compositions comprising a crystalline form of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil). Processes for the preparation of the crystalline forms and methods of treating bacterial infections by administering the crystalline forms alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil) are also described.

Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt

Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-Diazabicyclo[3,2,1]octane-2-carboxamide sodium salt

The disclosure relates to a method for preparing a compound of formula (I), wherein Pand Pare groups protecting the carboxylic acid and oxyamine functions, starting from pyroglutamic acid (S). The disclosure also relates to novel intermediates.

Method for preparing disubstituted piperidine and intermediates

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Paris, France

Alain Priour