Delalande S.a.

Delande S.a.

Alain P Lacour

Guy R Bourgery

Michel Langlois

Jean-Francois R Ancher

Patrick G Guerret

Bernard M Pourrias

Colette A Douzon

Philippe L Dostert

Bernard P Bucher

Gerard H Moinet

Raphael Santamaria

Phillippe L Dostert

Gisele C Mocquet

Margherita Strolin-Benedetti

Anne-Marie P Ruch

Genevieve C Bregeon

Alain Y Platel

Jacky A Tisne-Versailles

Maurice F Jalfre

New aromatic derivatives having an activity antagonistic to calcium and corresponding to formula: ##STR1## in which: A represents a chain having any one of the following structures: ##STR2## Ar represents a group of structure: ##STR3## n takes the value 1 or 2 when R is different from H; m takes the value 2 or 3.

Aromatic derivatives comprising an aminoalkoxy chain, the salts thereof,

Aromatic derivatives comprising an aminoalkoxy chain and pharmaceutical

New tetrazole derivatives, characterized in that they correspond to the formula: ##STR1## in which R.sub.1 represents: either a hydrogen atom in any one of the positions 1 to 5 of the tetrazole nucleus, R designating a branched alkyl group comprising at least 5 carbon atoms or a branched alkenyl group, or a methyl group in position 2(3) of the tetrazole nucleus, R representing the (1-propyl)n butyl chain. These new derivatives are useful as medicaments, more especially for their anti-epileptic action.

5-(1-Propyl)n-butyl tetrazoles

N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones are disclosed. These compounds possess antidepressant activity.

N-Substituted phenyl-5-aminomethyl oxazolidinones and their method of use

A compound of the formula ##STR1## where R is selected from the group consisting of CH.sub.3 --CO--(CH.sub.2).sub.2 --O--, ##STR2## The compounds are useful in treating depression.

-N-substituted phenyl-5-methoxymethyl-2-oxazolidinones and

A class of known (1-cinnamoyl or 1-phenylethylcarbonyl) piperazine derivatives have been found to be central nervous system stimulants effective to improve the mental alertness and to brighten the spirits of human beings.

Therapeutical use of (1-cinnamoyl or 1-phenethylcarbonyl) piperazine

Derivatives corresponding to the general formula: ##STR1## in which Ar represents a phenyl group; a phenyl group substituted by a halogen atom or by a trifluoromethyl group; or the (chloro-3 fluoro-4) phenyl group and n is either equal to zero or equal to 1 in which case X is a chain chosen from the following: --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 --O-- whose CH.sub.2 group is linked to Ar. These compounds are useful as medicaments more especially for the treatment of troubles of the central nervous system and senescence.

Aminomethyl-5 oxazolidinic derivatives and therapeutic use thereof

Method of treating the central nervous system troubles such as the Parkinson's disease and the senescence troubles, generally treated by the B type monoamine oxidase inhibitors, which comprises administering internally to a human being requiring such treatment a therapeutically effective amount of N-aryl 5-aminomethyl oxazolidine-2-one derivatives.

Therapeutical use of known 5-aminomethyl oxazolidine-2-one derivatives

N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines

Derivatives of formula: ##STR1## in which Z&lt; represents: either an amino group of struture &gt;N-R.sub.1 where R.sub.1 represents a linear or branched alkyl group with 1 to 5 carbon atoms or a phenyl group possibly substituted by a chlorine atom, in which case:

1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the

Derivatives of 5H-furanone-2 and 3H-dihydrofuranone-2, substituted at the 3 position with substituted phenyl and at the 5 position with substituted methyl, are prepared by various processes. The derivatives are inhibitors of monoamine oxidase and are useful for treating depression.

3H-Dihydrofuranone-2 derivatives and pharmaceutical use thereof

1-substituted-4-(3,4,5-trimethoxy) cinnamoyl piperazine compounds are disclosed. The compounds exhibit a substantial activity of stimulating cardiac contractile force, without affecting the cardiac frequency, and they also exhibit coronary vasodilatory and hypotensive effects.

Growing community of inventors

La Varenne, France

Alain P Lacour