The Scripps Research Institute

Alain Luxembourg

Per A Peterson

Michael R Jackson

Zeling Cai

Ann M Moriarty

Didier J Leturcq

Anders Brunmark

Jonathan Sprent

The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8 T-cells to produce cytokines and become cytotoxic.

Antigen presenting system and methods for activation of T-cells

Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a synthetic antigen presenting matrix for activating T lymphocytes to a specific peptide is described.

Synthetic antigen presenting matrix

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La Jolla, CA, United States of America

Alain Luxembourg