Adir Et Compagnie

Alain Lombet

Gilbert Regnier

Jean-Paul Vilaine

Camille-Georges Wermuth

Jean-Jacques Bourguignon

Catherine Thollon

Albert Lenaers

Jean-Pierre Bidouard

Jean-Pierre Iliou

De La Renaud

J F Benaud De La Faverie

New imidazo [1,2-c] quinazoline compounds useful as coronary smooth muscle relaxants and corresponding to the formula: ##STR1## in which: Y is oxygen or sulfur;

Imidazo [1,2-c] quinazoline compounds

The compounds disclosed are 1-R'-4-RS-piperidines in which R' and R, which are different, may each represent: (1) (alkoxybenzyl)-alkyl or -alkenyl, or (2) (optionally-substituted chromanyl-, thiochromanyl-, chromenyl- or thiochromenyl)-alkyl or -alkenyl. The compounds are useful in the treatment of disorders associated with tissue ischaemia and of peripheral vascular disorders or in the treatment of disorders in which lipid peroxidation plays an initiating and/or aggravating role. A typical disclosed compound is: 4-(2,3,4-tirmethoxybenzylthio)-1-(3,5-di- tert-butyl-4-hydroxybenzyl)piperidine. ,3,4-trimethoxybenzylthio)-1-(3,5-di-tert-butyl-4-hydroxybenzyl)piperidine .

Piperidine compounds

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Champigny, France

Alain Lombet