Flamel Technologies

Monsanto Technology LLC

Alain Lemercier

Gerard Soula

Ronald Joseph Brinker

Olivier Soula

Sylvain Huille

Remi Meyrueix

The present invention provides guanidine compounds and salts thereof that may be useful, for example, in the preparation of herbicidal compositions. The compounds may be used, for example, to prepare N-phosphonomethylglycine guanidine salts having improved herbicidal efficacy over glyphosate alone.

Guanidine derivative compounds

The present invention provides N-phosphonomethylglycine guanidine salts. The N-phosphonomethylglycine guanidine salts have improved herbicidal efficacy over glyphosate alone. The present invention also provides guanidine compounds and salts thereof. 

N-phosphonomethylglycine guanidine derivative salts

The invention relates to vectors for delivering medicinal, nutritional, plant-protection or cosmetic active principles, these delivery particles being of small, controllable and adjustable particle size, which protect the active principle, and being biocompatible, biodegradable, non-immunogenic, stable and free of solvent. The particles do not denature the active principle and allow the active principle to be released. The microparticles of the invention are of a cohesive structure made of a physicochemically stable and integral composite gel which includes an oil such as coconut oil, an aqueous phase and a linear, non-crosslinked copolyamino acid of Leu/Glu type (random or diblock). The microparticles have a controllable and adjustable size of between 0.05 and 500 &mgr;m.

Composite gel microparticles as active principle carriers

The present invention relates to delivery vehicles which are useful for the administration of active principles (APs), preferably medicinal or nutritional active principles, in particular via the oral or parenteral route. The technical problem solved by the invention is that which consists in providing delivery vehicles composed of (nano)- or (micro)particles based on polyamino acids, and which are invert with respect to the AP (proteins), of controllable particle size, strong and inexpensive. According to the invention, the particles have an average size of less than 200 .mu.m and consist of a polyamino acid of the Leu/Glu type, in which Leu/Glu+Leu.gtoreq.3% and the M.sub.w .gtoreq.4,000 D.

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Venissieux, France

Alain Lemercier