Sanofi-a Ventis Deutschland Gmbh

Aventis Pharma S.a.

Rhone-poulenc Rorer S.a.

Phone-poulenc Rorer Sa.

Alain Le Brun

Pascal Desmazeau

Heinz-Werner Kleemann

Serge Mignani

Jean-Christophe Carry

Michel Tabart

Alain Commercon

Frank Halley

Arielle Genevois-Borella

Patrick Mailliet

Michel Evers

Fabrice Viviani

Gilles Doerflinger

Bruno Filoche-Romme

Hervé Bouchard

Alain Commercedillaon

Jean-Paul Martin

Alain Truchon

Catherine Souaille

Bernard Baudoin

Laurence Gauzy-Lazo

Odile Angouillant-Boniface

Fabienne Sounigo-Thompson

Jean-Francedillaois Peyronel

Christopher Burns

Martine Zucco

Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.

Substituted indazoles, compositions containing the same, and the preparation and use thereof

The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.

Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom

4,9-ethano-benzo(F)isoindole derivatives as farnesyl transferase

Farnesyl transferase inhibitors, preparation thereof and pharmaceutical

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Vigneux, France

Alain Le Brun