Transfert Plus, S.e.c.

Angiochem Inc.

Alain Larocque

Michel Demeule

Richard Béliveau

Jean-Christophe Currie

Borhane Annabi

Cyndia Charfi

Sasmita Tripathy

Gaoqiang Yang

Richard BÉLIVEAU

The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer. For example, the compounds can comprise compounds of formula

Peptide compounds and peptide conjugates for the treatment of cancer through receptor-mediated chemotherapy

The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer and increasing cellular internalization of said peptide compounds. The peptide compounds are selected from the following group consisting of; GVRAKAGVRNMFKSESY as set forth in SEQ ID NO: 9; GVRAKAGVRN(Nle)FKSESY as set forth in SEQ ID NO: 10; and YKSLRRKAPRWDAPLRDPALRQLL as set forth in SEQ ID NO: 11; and wherein at least one protecting group and/or at least one labelling agent is connected to said peptide compound.

The invention relates to dendrimers conjugated to multiple targeting peptides and one or more therapeutic, diagnostic, or imaging agents for delivery of such agents across the blood-brain barrier and into certain cell types including, cells expressing the LRP-1 receptor. Also described are methods of making compounds that comprise dendrimers conjugated to targeting peptides and therapeutic, diagnostic, or imaging agents.

Peptide-dendrimer conjugates and uses thereof

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St-Laurent, Canada

Alain Larocque