Institut Merieux

Pasteur Merieux Serums & Vaccins

Alain Genet

Michel Galy

Assembly for the distribution of a pharmaceutical solution, contained in multi-dose vial, into single-dose carpules for single use, comprising single-dose carpules and a distribution apparatus, in which assembly pressure and suction means are provided to circulate a liquid from the carpules to the vial and from the vial to the carpules, by means of a network of channels.

Assembly for the distribution of a pharmaceutical solution in a multi-dose vial into single-dose capsules for single use

Process for the preparation in a series of self-injectable syringes characterized mainly by the fact that multiple seal tubes are placed vertically on an appropriate support, that a syringe body is placed vertically in each seal tube, that, into each tubular body thus arranged, a single dose of the medication in solution in a solvent is placed in each seal tube, above the syringe body, a plunger suspended by its pusher in a movable manner, at the lower end of a stopper which can adapt to the seal tube, so that said plunger is essentially in the axis of the syringe body and the lower end of said plunger is located above the upper end of the syringe body, with said stopper being held in a position so that said seal tube is not blocked or is not entirely blocked, to thus obtain an assembly constituting an open system in which the internal space, in the seal tubes and above said solution in the syringe bodies, is connected with the outside of the system, that the lyophilization operation is effected and, at this time, downward vertical pressure applied to the stoppers so that said stoppers completely block said seal tubes while said plungers, fastened to said stoppers, are introduced into the tubular bodies until the predetermined maximum insertion position is reached; a device and stopper for the implementation of said process.

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Ecully, France

Alain Genet