Sanofi Pasteur Inc.

Aventis Pasteur S.a.

Pasteur Merieux Serums Et Vaccins

Pasteur Merieux Serums & Vaccins

Pasteur Merteux Serums Et Vaccins Societe Anonyme

Aventis Pasteur Limited

Alain Françon

Bernard Fanget

Pierre Chouvenc

Sandrine Lentsch Graf

Isabelle Chacornac

Olivier Brass

Jean-Marc Contzen

Landry Bertaux

Catherine Noël

Jean-François Hau

Pierre Heimendinger

Amandine Leleu

Jean-Francois Hau

Michel Tardy

The subject matter of the invention is a method for preparing a vaccine composition comprising at least aluminum oxyhydroxide (AlOOH), and at least the hepatitis B surface antigen and thetype b antigen. According to the invention, the hepatitis B surface antigen is kept adsorbed on the AlOOH, whereas the Hib antigen is kept nonadsorbed. To this end: the hepatitis B surface antigen is adsorbed onto AlOOH in order to obtain an AlOOH/HBsAg complex, then&#x2014;said AlOOH/HBsAg complex is mixed with the Hib antigen in the presence of cationic amino acids at a concentration of at least 100 mg/l, and of phosphate ions at a concentration of 35 to 45 mMol/l.

Method for formulating a vaccine containing at least two antigens capable of adsorbing onto aluminium oxyhydroxide

The present invention relates to stabilizers for compositions, including immunogenic compositions, such as vaccine compositions, comprising one or more live attenuated flaviviruses, to bulk vaccine compositions stabilized with these stabilizers, particularly dry vaccine compositions prepared from these bulk vaccine compositions, and to methods for stabilizing one or more live attenuated flaviviruses.

Stabilizer and vaccine composition comprising one or more live attenuated flaviviruses

A vaccine composition comprising two valences is provided: (i) a first valence which is adjuvant-enhanced with aluminum hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more o-acetyl groups and which is not adsorbed with aluminum oxide due to the presence of a protecting compound which may be a phosphate, a citrate or a carbonate and which prevents the adsorption. The first valence can be any vaccine valence. In one particular embodiment, the vaccine composition contains (i) Hepatitis A valence, adsorbed on aluminum hydroxide and (ii) the typhoid fever valence formed by the polysaccharide Vi of thecapsule.

Multivalent vaccine composition having increased stability of capsular polysaccharide

The invention concerns the stabilization of a vaccine composition maintained in liquid state by the use of high molecular weight polyvinylpyrrolidone, hence eliminating the use of albumen. The invention is of particular interest for vaccine compositions comprising attenuated live viruses such as oral vaccine against poliomyelitis.

Vaccine composition and stabilization method using high molecular weight PVP

Stabilizers for live vaccines and attenuated mono- or multivalent live vaccines, stabilized vaccines containig such stabilizers, and methods for preparing such vaccines, are disclosed. Said stabilizers for vaccines containing one or more attenuated live viruses include one or more components selected from each of the following groups: amino acids, disaccharides, polyalcohols and buffer solutions, with the proviso that one component selected from the disaccharide group is saccharose.

Stabilizers for live vaccines

Industrial production process for a vaccine against Japanese

Method for purifying viruses by chromatography

Process for preparing hepatitis A (HAV) antigens and vaccines. The HAV virus is multiplied on competent cells, the infected cells are lysed, the supernatant is recovered and the purification is carried out by a chromatographic procedure on an anion-exchange support and a gel filtration procedure, the purification procedures being carried out in the presence of a detergent, and the chromatographic procedure being carried out under conditions which retain the virions or viral capsids, which are then eluted.

Process for preparing hepatitis A (HAV) antigens and vaccines

Growing community of inventors

Bessenay, France

Alain Françon