Commissariat a L'energie Atomique

Université Joseph Fourier

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Alain Favier

Michel Seve

Provided are antibodies specific for ZnT8. In particular, provided are monoclonal or polyclonal non-naturally occurring antibodies which specifically recognizes an epitope selected from the group consisting of SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID NO. 9 and SEQ ID NO. 10 as described herein.

Antibodies specific for ZNT8

The invention relates to protein ZnT-8 which is specifically expressed in the pancreatic beta cells in islets of Langerhans, to a polynucleotide encoding said protein which is involved in the maturation and exocytosis of insulin, and to the applications thereof, for example, for sorting and studying beta cells and for screening medicine acting on diabetes and hyperinsulinism.

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Bernin, France

Alain Favier