Dow Corning France, S.a.

Biovector Therapeutics, S.a.

Alain Etienne

Louis M Aguadisch

Ignacio De Miguel

Didier Betbeder

Roger Kravtzoff

Michel Major

Patrick Robert Peignot

Frederic Jean Goutte

The invention relates to a process for making a controlled release device suitable for introduction into a human or animal body. The process comprises coextruding a continuous external body comprising a silicone elastomer and one or more elements comprising a synthetic pharmaceutical agent within the continuous external body.

Methods for making controlled release devices for pharmaceuticals

A novel method for the mucosal administration of a substance to a mammal is provided. The method comprises contacting a mucosal surface of the mammal with the substance in combination with a Biovector. The Biovector has a core that comprises a natural polymer, or a derivative or a hydrolysate of a natural polymer, or a mixture thereof. A preferred natural polymer is a polysaccharide or an oligosaccharide. The core is optionally coated with an amphiphilic compound, such as a lipid.

Mucosal administration of substances to mammals

The invention concerns a sustained release formulation comprising an agent (A) which is to be released and a vehicle (B) therefor. The vehicle comprises a hydrophilic component such as a polyhydroxylated organic substance such as a polyethylene glycol, glycerol, sorbitol, mannitol or lactose and curable silicone composition which is capable of curing at ambient temperature and contains a polysiloxane having alkylhydrogen units, a polysiloxane having unsaturated groups and a platinum or rhodium catalyst. The formulation may be applied to the human or animal body or a cavity in the latter to cure in situ to give a dressing capable of sustained release of the therapeutic or diagnostic agent (A) to the body. The invention is applicable in the field of pharmacy.

Formulations for sustained release dressings and their use

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Toulouse, France

Alain Etienne