Universite D' Auvergne Clermont I

UniversitÉ Paris Descartes

Université Clermont Auvergne

Université D'auvergne

Ecole Nationale Superieure De Chimie De Clermont Ferrand

Centre Hospitalier Universitaire De Clermont Ferrand

Alain Eschalier

Jérôme Busserolles

Michel Lazdunski

Abdelkrim Alloui

Florian Lesage

Jean-Philippe Pin

Francine Acher

Nuno Rodrigues

Cyril Goudet

Sylvie Ducki

Jéröme Busserolles

Delphine Rigault

Delphine Vivier

Isabelle Lemasson

Khalil Bennis

Sara Cesarini

Bruno Commare

David Balayssac

Fabien Marchand

Jerome Busserolles

Jérémy Ferrier

The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.

Pain relief compounds

This invention relates to riluzole for use in the treatment or prevention of adverse effects associated with the administration of anticancer agents having neurotoxic effects, such as, for example, platinum salts, taxanes and periwinkle alkaloids.

Use of riluzole for treating or preventing the adverse effects of antineoplastic agents

The present invention relates to treating and preventing pain. More particularly the present invention demonstrates the involvement of K2P potassium channels in the antalgic effect of morphine. The present invention therefore provides a screening method for identifying antalgics.

Use of K2P potassium channel activators as antalgics

The invention relates to hypophosphorous acid derivatives of formula (I) wherein &#x2014;X is H or OH, &#x2014;R represents one or several radicals R-R, identical or different, two of R-Roptionally occupying the same position on the phenyl group, one to four of R-Rbeing H and the others being selected in the group comprising -0-(CH)&#x2014;COOH; &#x2014;S&#x2014;(CH)&#x2014;COOH; &#x2014;NH&#x2014;(CH)&#x2014;COOH; -0-(CH,R')&#x2014;COOH; &#x2014;O&#x2014;(CH)&#x2014;OH; OR&#x2032;, &#x2014;R&#x2032; being a C-Calkyl radical; &#x2014;OH; &#x2014;COOH; halogen, particularly &#x2014;F, &#x2014;CI, &#x2014;Br, &#x2014;I, &#x2014;CF; &#x2014;OCF; &#x2014;N0; &#x2014;CH&#x2550;CH&#x2014;COOH; &#x2014;(CH)&#x2014;COOH; O&#x2014;(CH)&#x2014;P0H; O&#x2014;(CF)&#x2014;P0H; O&#x2014;(CH)&#x2014;S0H; O&#x2014;(CH)&#x2014;CONHOH; O&#x2014;(CH)-tetrazol; O&#x2014;(CH)-hydroxyisoxazol&#x2014;n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers. 

Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof

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Chamalieres, France

Alain Eschalier