Adir Et Compagnie

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Adir

Science Union Et Cie

Adir Et Cie

Science Union Et Cie, Societe Francaise De Recherche Medicale

Adir, S.a.r.l.

Alain Dhainaut

Gilbert Regnier

Pierre Lestage

Ghanem Atassi

Jacques Duhault

Michel Lonchampt

Michel Laubie

Alain Pierre

Patrick Casara

Jacques DuHault

Anne-Marie Chollet

Jean Lepagnol

Michelle Boulanger

Emmanuel Canet

Brian Lockhart

Stephane Leonce

Andre Tizot

Fany Panayi

Jean-Paul Vilaine

Nicole Villeneuve

Yves Rolland

Solo Goldstein

Guillaume Poissonnet

Guy Lewin

Francois Roman

Anita Roger

Lionel Bert

Gilbert Regnir

Ghislaine Joly

Xavier Leverve

Bernard Paramelle

Emmanuel Canft

Compounds of formula (I): wherein:  Medicinal products containing the same which are useful in the treatment of conditions associated with central histaminergic systems.

Azabicyclo[3.2.0] hept-3-yl compounds, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein:  Medicinal products containing the same which are useful in the treatment of cognitive and psycho-behavioural disorders associated with cerebral ageing, with neurodegenerative diseases or with cranial traumas and also in the treatment of mood disorders, of schizophrenia and of cognitive disorders associated therewith, of sleep disorders, of sleep-waking rhythm disorders, of attention-deficit hyperactivity syndrome or of obesity.

Azabicylic compounds, a process for their preparation and pharmaceutical compositions containing them

A compound selected from those of formula (I): wherein Medicinal products containing the same which are useful for treating conditions associated with central histaminergic systems.

Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them

A compound selected from those of formula (1): ##STR1## wherein W represents aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each being optionally substituted,

Nitrone compounds

New N-substituted cyclic amines of formula: ##STR1## wherein: X, R.sub.1, R.sub.2 and R are as defined in the description, their optical and geometric isomers and physiologically tolerable salts thereof. The compounds of the invention are powerful PDE4 inhibitors and can be used therapeutically.

N-substituted piperidines as PDE4 inhibitors

A compound of general formula (I): ##STR1## in which: R.sub.1 represents alkyl,

Flavone compounds

A compound of formula (I): ##STR1## wherein: R.sub.1 represents unsubstituted or substituted cycloalkyl, phenyl, naphthyl, heterocyclic, alkyl or alkenyl,

Substituted biphenyl compounds

Bicyclic pyrimidines

The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents. A compound disclosed is 2,4-diallylamino-6-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl) methylamino]piperidin-1-yl}-1,3,5-triazine.

Trisubstituted triazines

The compounds are 2,4-(optionally substituted amino)-6-substituted s.triazines, useful for suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents. A compound disclosed is 1-[4,6-bis(allylamino)-2-s-triazinyl]-4-[2,2-bis(p.fluorophenyl)ethylamino ]piperidine.

Disubstituted polymethyleneimines

The invention relates to the use, for obtaining medicaments that reverse resistance to anti-cancer and anti-malarial agents, of compounds of formula I: ##STR1## in which A is --CH-- or nitrogen,

Use of triazine and pyrimidine compounds for obtaining medicaments that

New pyrrolidone compounds of the formula: ##STR1## in which: R is OR', SR' or N (R.sub.3 R.sub.4)

Pyrrolidone compounds for treating cerebral disorders

New aminochromanol compounds of the formula: ##STR1## in which X is cyano, nitro, trifluoromethyl, alkoxycarbonyl, carbamido, dialkylcarbamido, aminosulfonyl, dialkylaminosulfonyl, alkylsulfonyl, alkylsulfonylamino or acyl;

New aminochromanol compounds

New benzopyrrolidinone compounds, which can be used as medicaments and correspond to the formula ##STR1## in which: either: R.sub.1 and R.sub.2 together represent, with the bond of the etherocycle to which they are attached, an optionally substituted benzene nucleus and, simultaneously, R.sub.3 and R.sub.4 are hydrogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.5 -C.sub.6)cycloalkyl; or:

Benzopyrrolidinone compounds as bronchospastic agents

Disubstituted polymethylene imines of the formula: ##STR1## in which: A is a straight or branched chain (C.sub.3 -C.sub.5) hydrocarbon containing radical optionally containing one or two double bond and optionally substituted by one or more hydroxy;

Growing community of inventors

Chatou, France

Alain Dhainaut