Roussel Uclaf

Other

Aventis Pharma S.a.

Hoechst Marion Roussel

Alain Corbier

Michel Fortin

Jacques Guillaume

Jean Paul Vevert

Gilles Hamon

Jean-Luc Haesslein

Jean-Paul Vevert

Simone Jouquey

Pierre Deprez

Jean C Caille

Bertrand Heckmann

Laurent Schio

Patrick Fauveau

Jidong Zhang

Nathalie Pietre-Dischamp

Pascale Vicat

A subject of the invention is the compounds of formula (I):in which The products have of the antifungal properties.

Echinocandin derivatives, method for preparing same and use as antifungal agents

Products of formula (1), wherein R.sub.1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R.sub.2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R.sub.3 is particularly carboxy, acyl, halogen, alkyl, alkenyl or alkylthio; and R.sub.4 is particularly --(CH.sub.2).sub.m1 --COOR.sub.4, --(CH.sub.2).sub.m1 --CONHR.sub.14, --(CH.sub.2).sub.m1 --CN, --SO.sub.2 --NH--SO.sub.2 --R.sub.14, 13 NH--SO.sub.2 --R.sub.14, --PO.sub.3 R.sub.14, or --NH--SO.sub.2 --CF.sub.3, where m1 is 0-4 and R.sub.14 is hydrogen, alkyl or alkenyl; are useful for preparing pharmaceutical compositions for treating disorders resulting from abnormal stimulation of angiotensin II receptors AT.sub.1 and AT.sub.2.

Imidazole-5-carboxamides

Method of preventing abnormal stimulation of AT.sub.1 and AT.sub.2

Tetrasubstituted imidazoles

Described herein are compounds of the formula ##STR1## wherein the substituents are defined as in the specification having inhibiting activity on the effects of angiotensin II.

Bicycle Derivatives of imidazole

The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.

Method for inhibiting vasoconstriction

Novel compounds of the formula ##STR1## wherein the, substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable salts which inhibit the effects of angiotensin II in warm-blooded animals.

Sulphorous derivatives of imidazole, their preparation process, the new

Method of inhibiting angiotensin effects

The invention relates to the products: ##STR1## in which: R.sub.1 =alkyl, alkenyl, alkynyl, alkylthio,

Sulphorous derivatives of imidazole and their use as medicaments

Bicyclic pyridines which are angiotensin II inhibitors

Sulphorous derivatives of imidazole, and their use as medicaments and

Growing community of inventors

Verrieres le Buisson, France

Alain Corbier