C M Industries

Alain Calvet

Francois Krausz

Novel derivatives of midecamycine, of the formula: ##STR1## wherein X represents an oxygen atom or a sulphur atom, R.sub.1 represents a straight or branched alkyl group, an alkenyl group or an aryl group, R.sub.2 represents a hydrogen atom or a lower acyl group, the dotted lines represent the possible presence of double bonds, it being understood that the 2 double bonds at the 10,11 position on the one hand and the 12,13 position on the other either exist simultaneously or neither of them exists, which give by oral administration plasma rates which are higher than midecamycine and which lack its bitter taste, together with their process of preparation.

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Montpellier, France

Alain Calvet