Maquet Cardiovascular LLC

Meadox Medicals, Inc.

Scimed Life Systems, Inc.

Al Kuehn

Moon Hae Sunwoo

Dan Castro

An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.

Self-aggregating protein compositions and use as sealants

There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25&#xb0; C. and a pH sufficient to maintain the protein suspended in the slurry.

There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25&deg; C. and a pH sufficient to maintain the protein suspended in the slurry.

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Wayne, NJ, United States of America

Al Kuehn