Biocon Limited

Akundi Venkata Sriram

Ramakrishnan Melarkode

Kedarnath Nanjund Sastry

Shrikumar Suryanarayan

Lakshmi Prabha Varadarajalu

The present invention relates to a method of producing a biologically active polypeptide having insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified host cell that has protease gene knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformed host cell to produce the biologically active polypeptide; and a method of producing a biologically active polypeptide having an N-terminal recognition site His-Gly with insulinotropic activity, the method comprising steps of: (a) transforming a genetically modifiedthat has protease gene STE13 knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformedto produce the biologically active polypeptide.

Growing community of inventors

Bengaluru, India

Akundi Venkata Sriram