Arcus Biosciences, Inc.

Akshata R Udyavar

Stephen W Young

Matthew J Walters

Amy Elizabeth Anderson

Devika Ashok

Joanne Bl Tan

Daniel M DiRenzo

The present disclosure provides methods of treating a subject identified as having an oncogene driven cancer comprising administering to said subject an agent targeting the extracellular production of adenosine and/or an agent antagonizing the activation by adenosine of one of its receptors.

Treatment of oncogene-driven cancers

The present disclosure provides methods of treating a cancer in a subject having an established adenosine fingerprint. An established adenosine fingerprint includes assessing the blood concentration of one or more adenosine machinery proteins, assessing the enzymatic activity of one or more adenosine machinery proteins, and/or assessing the tumor expression level of adenosine machinery proteins. The methods disclosed herein include administering to said subjects a therapeutic agent selected from the group consisting of an agent targeting the extracellular production of adenosine, and an agent antagonizing the activation by adenosine of one of its receptors.

Treatment of cancer utilizing an identified adenosine fingerprint

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Foster City, CA, United States of America

Akshata R Udyavar