Rohto Pharmaceutical Co., Ltd.

Akiyoshi Yoshida

Shigeru Kametaka

Shin'ichi Hayashi

Tetsuo Koike

A pharmaceutical composition for the prevention of dental caries which comprises as essential component(s) one or more of pentacyclic acid triterpenes of the formula: ##STR1## wherein R.sub.1 represents CH.sub.3, CHO or CH.sub.2 OH, R.sub.2 and R.sub.3 independently represent CH.sub.3 or COOH, R.sub.4 represents H, CH.sub.3, COOH or COOCH.sub.3, R.sub.5 and R.sub.6 independently represent H, CH.sub.3 or OH, and A represents two Hs or O, and their salts.

Pharmaceutical composition for the prevention of dental caries

A method of enhancing a fungus-lytic activity of .beta.-1,3-D-glucanase which comprises using said glucanase in the presence of one or more of the activators selected from the group consisting of sodium lauroylsarcosinate, polyoxyethylene alkylphenyl ether, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylenealkyl ether, benzalkonium chloride, ammonium chloride, chlorhexidine glucuronate, methylparaben, propylparaben, trypsin, Pronase.RTM. and Alcalase.RTM.. A method of enhancing a fungus-lytic activity of .beta.-1,3-D-glucanase which comprises using two .beta.-1,3-D-glucanases of different origins is also provided.

Method for enhancing a fungus-lytic activity of .beta.-1,3-D-glucanase

A cleaning composition for an artificial denture which comprises .beta.-1,3-glucanase as an essential component together with one or more of suitable carriers.

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Nara, Japan

Akiyoshi Yoshida