Seikagaku Kogyo Co. Ltd.

Mitsubishi Chemical Industries Limited

Seikagaku Corporation

Other

Seikagaku Kogyo K.k.

Akiyoshi Matsumoto

Michinori Waki

Tadashi Hishida

Yoshimasa Fujita

Akira Kamata

Isao Kawakami

Naoki Yamamoto

Nobutaka Fujii

Nobuo Imai

Isao Miyachi

Hiroshi Tamura

Shigenori Tanaka

Chizuko Nakahara

Hachiro Ishikawa

Hiroshi Takamisawa

Yusuke Maeda

Hideo Kato

The present invention provides a novel salt compound of a polypeptide represented by formula I and a transition metal which has high antiviral activity against human immunodeficiency virus (HIV).

Polypeptide transition metal salts and method of enhancing anti-HIV activity of polypeptide

Polypeptide and anti-HIV agent prepared therefrom

A novel polypeptide sequence having the formula ##STR1## in which A.sub.1 is a hydrogen or at least one and no more than two amino acids selected from the group consisting of lysine and arginine,

Pharmaceutical compositions of lipopolysaccharide-binding polypeptides

A novel polypeptide sequence having the formula ##STR1## in which A.sub.1 is a hydrogen or at least one and no more than two amino acids selected from the group consisting of lysine and arginine, A.sub.2 is a tyrosine, phenylalanine or tryptophan residue, A.sub.3 is an arginine or lysine residue, A.sub.4 is at least one and no more than two amino acids selected from the group consisting of lysine and arginine, and A.sub.5 is an --OH or an NH.sub.2, is described. The polypeptide may be used in a pharmaceutical composition as an antimicrobial or antiviral agent, specifically as an anti-HIV agent.

Polypeptides with affinity to lipopolysaccharides and their uses

Bacterial endotoxin in an assay sample is determined by an amoebocyte lysate component of horseshoe crab in the presence or absence of a substrate for endotoxin determination by using an assay sample in the liquid state obtained by treating said assay sample with an endotoxin-free acid having a pKa.sup.25.degree. C. value of not more than 3 at a pH of not more than 3; and a kit therefor, a receptacle containing (a) an endotoxin-free acid having a pKa.sup.25.degree. C. value of not more than 3 e.g. perchloric acid, trichloroacetic acid, nitric acid, for treating the assay sample and a receptacle containing (b) an amoebocyte lysate component or horseshoe crab. The acid treatment of the assay sample results in improved accuracy, reliability and reproducibility of the bacterial endotoxin determination.

Method for determining bacterial endotoxin and kit therefor

There is disclosed a process for the renewal of a deactivated insolubilized glucose isomerase which comprises subjecting an insolubilized glucose isomerase adsorbed onto an anion exchange resin, which has been used for isomerization of glucose into fructose to decrease its activity, to treatments by an aqueous mineral acid solution in combination with an aqueous alkaline solution, an aqueous electrolytic salt solution, an aqueous mineral acid or a mixture thereof to release adsorbed materials from the resin which is converted into a salt type and adsorbing fresh glucose isomerase to the regenerated resin to recover the activity of the insolubilized glucose isomerase.

Process for the renewal of an insolubilized glucose isomerase

There is disclosed a process for producing an insolubilized glucose isomerase useful for converting glucose into fructose comprising contacting a macroporous anion exchange resin with glucose isomerase to effect absorption of the isomerase on the resin, said resin having high porosity and high ion exchange capacity, whereby the resulted insolubilized glucose isomerase has high degree of adsorption, high activity retention and high activity yield.

Insolubilized glucose isomerase

There is disclosed a process for isomerization of glucose into fructose which comprises contacting an aqueous glucose solution with glucose isomerase in the presence of iron ion and magnesium ion, said glucose isomerase being in the form of insolubilized glucose isomerase adsorbed on a carrier.

Process for the isomerization of glucose into fructose

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Hino, Japan

Akiyoshi Matsumoto