Otsuka Pharmaceutical Factory, Inc.

Akiyoshi Kuroda

Norihiro Yoshinaga

Yoshihiko Tsuda

Yasuhide Inoue

Kazuyoshi Miyata

Masako Doi

Akifumi Hagi

Yasuhiro Sakai

Shinya Miki

Seiichirou Kanou

Takahiro Tomoyasu

The present invention provides a phosphonic acid diester compound represented by General Formula wherein R, R, Rand Rare the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; Ris phenyl having on the phenyl ring 1&#x2013;3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that Ris not mono(lower alkoxy)pheny; and Ris lower alkyl;and an ACAT-1 inhibitor containing the compound as an active ingredient.

Phosphonic diester derivatives

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Saitama, Japan

Akiyoshi Kuroda