Ajinomoto Co., Ltd.

Akiyo Yamazaki

Seiji Niwa

Takao Ikenoue

Ryusuke Hirama

Toshihiro Hatanaka

Nobuo Kondo

Yoko Masuzawa

Takashi Yamamoto

Hideyuki Tanaka

Hiroyuki Matsueda

Yukio Iino

Fumio Ohta

Masaru Takayanagi

Wataru Miyanaga

Koji Ohsumi

The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R' represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R&#x2033; represent a hydrogen atom.

Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof

The following fused polycyclic compound, analogues thereof or pharmaceutically acceptable salts thereof have an effect of increasing the sugar-transporting capacity and an effect of lowering the blood glucose level and, therefore, they are useful for preventing and/or treating diabetes and the like. wherein R is a methoxy group, Y is a (2-thiazolyl)-2-ethylcarbonyl group, Rand Rare hydrogen atoms, and Rand Rare methyl groups.

Fused polycyclic compounds

An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.

Lactam compounds and pharmaceutical use thereof

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Kawasaki, Japan

Akiyo Yamazaki