Teikoku Seiyaku Kabushiki Kaisha

Teikoku Seiyaku Co., Ltd.

Asahi Kasei Kogyo Kabushiki Kaisha

Akiya Yamada

Shigeyuki Takama

Takeru Fujii

Toru Hibi

Yukiko Inamoto

Takahiko Wato

Seiichi Sako

Naoki Uchida

Seiichi Sakoh

Misuzu Kadoriku

Misuzu Fujisawa

A pharmaceutical composition comprising a physiologically active polypeptide, an absorption promoting agent consisting of a combination of an organic acid and a fatty acid sucrose ester in admixture with a pharmaceutically acceptable carrier or diluent, which is suitable for oral administration and for application to the oral cavity, by which the polypeptide can sufficiently be absorbed through the intestinal tract or the mucous membrane in the oral cavity and exhibit the physiological activities without being suffered from enzymolysis.

Physiologically active polypeptide-containing pharmaceutical composition

Pharmaceutical compositions of matter adapted for intravaginal administration comprise a biologically active polypeptide, an absorption promoter, such as an anionic and/or nonionic surfactant or a nonionic surfactant and an aliphatic carboxylic acid, optionally an animal and/or vegetable protein and a nontoxic pharmaceutically acceptable carrier or diluent therefor, in a formulation suitable for intravaginal administration. Preferred compositions comprise calcitonin as the biologically active polypeptide. Preferred absorption promoters are anionic surfactants, e.g., sodium lauryl sulfate, and the combination absorption promoter of a nonionic surfactant and a medium chain aliphatic carboxylic acid or its salt, e.g. polyoxyethylenealkylphenylether and a medium chain aliphatic carboxylic acid.

Intravaginal delivery of biologically active polypeptides

Oral pharmaceutical preparation released at infragastrointestinal tract

A high-absorbable transvaginal preparation having excellent absorbability of the active ingredient, which comprises a biologically active polypeptide and an absorption promoter comprising a polyoxyethylenealkylphenyl ether and one or more compounds selected from the group consisting of an N-acylamino acid, cholic acids, pectic acid, taurine, saccharin, glycyrrhizic acid, aspartame, or a salt thereof.

High-absorbable transvaginal preparation containing biologically active

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Takamatsu, Japan

Akiya Yamada