Yamanouchi Pharmaceutical Company Ltd.

Ferring B.v.

Ferring-research Limited

Akito Nishida

Masato Satoh

Mitsuaki Ohta

Keiji Miyata

Graeme Semple

Michael Szelke

Hamish Ryder

David Alan Kendrick

Masayuki Saito

Yoshinori Okamoto

Kazuo Honda

Yutaka Kondoh

Masato Ishii

A benzodiazepine derivative of formula (I), or a pharmaceutically acceptable salt thereof, wherein (a) R.sup.1 is --CH.sub.2 CHOH(CH.sub.2).sub.a R.sup.4 or a ketone group --CH.sub.2 CO(CH.sub.2).sub.a R.sup.5 in which a is 0 or 1 and R.sup.4 and R.sup.5 are selected from alkyl and cycloalkyl groups and saturated heterocyclic groups optionally substituted at a hetero-atom; (b) R.sup.2 and R.sup.3 are independently selected from aromatic carbocyclic and heterocylic residues; and (c) W and X are selected independently from halogen and hydrogen atoms and alkyl and alkoxy groups. These compounds are gastrin and/or CCK-B receptor antagonists. ##STR1##

Benzodiazepin derivatives useful as CCK-receptor antagonists

Process of preparing benzodiazepine compounds useful as antagonists of

Benzodiazepine derivatives useful as CCK-receptor antagonists

This invention relates to novel benzodiazepine derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, ##STR1## (wherein R.sup.1 is an aryl group, or an aromatic heterocyclic radical of 5-membered monocyclic, 6-membered monocyclic or 5- and 6-membered bicyclic structure, which may optionally be substituted; and R.sup.2 is an aryl group which may optionally be substituted), to medicinal compositions comprising the same, and to a process for producing the same. The compounds of formula (I) shown above exhibit antagonism for the CCK-B receptor and the action of depressing the gastric acid secretion caused by the stimulus of pentagastrin, and are therefore useful as a drug for the relief of diseases related to the CCK-B receptor and the gastrin receptor.

Benzodiazepine aryl urea derivatives

Growing community of inventors

Ibaraki, Japan

Akito Nishida