Ono Pharmaceutical Co., Ltd.

Ono Pharmaceuticalco.,ltd.

Akito Kakuuchi

Hiroshi Yamamoto

Atsushi Naganawa

Kensuke Kusumi

Tetsuya Sekiguchi

Shigeyuki Nonaka

Kazuhiro Otsuki

Koji Shinozaki

Hidenori Takahashi

Masaki Asada

Yan Zhang

Goran Krilov

Mats Svensson

Anatoly Ruvinsky

Shuhei Umemura

Daigo Inoyama

Kyle Konze

Disclosed are compounds of following formula (I): in which all symbols have the same meanings as the definitions described in the specification; or a salt thereof. The compounds or a salt thereof are useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.

Compound having KDM5 inhibitory activity and pharmaceutical use thereof

The compound of the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1Pantagonistic activity. The compound may therefore be used as a therapeutic agent for S1P-mediated diseases such as diseases resulting from vascular constriction, fibrosis, and respiratory diseases.

Phenyl derivative

The compound represented by the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1Pantagonistic activity. The compound may therefore be used as a therapeutic agent for S1P-mediated diseases such as diseases resulting from vascular constriction, fibrosis and respiratory diseases.

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Osaka, Japan

Akito Kakuuchi