Daiichi Sankyo Company, Limited

Akitake Yamaguchi

Hideaki Watanabe

Toru Taniguchi

Keisuke Yoshida

Hitoshi Ohki

Yoshihiro Shibata

Shoko Yoshida

Kouichi Uoto

Yuuichi Sugimoto

Masahiro Ota

Yuichi Tominaga

Masaki Miyazaki

Katsuhiro Kobayashi

Takeshi Jimbo

Masaki Setoguchi

Daisuke Fukatsu

Keijiro Kobayashi

Kosuke Takeuchi

Takanori Wakabayashi

Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R, R, R, R, R, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.

Pyridone derivatives

A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R, R, R, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification. 

Dispiropyrrolidine derivatives

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Tokyo, Japan

Akitake Yamaguchi