University of California

University of Southern California

Biovinc LLC

Akishige Hokugo

Charles E McKenna

Ichiro Nishimura

Frank Hallock Ebetino

Shuting Sun

Mark Walden Lundy

Keivan Sadrerafi

Boris A Kashemirov

Eric T Richard

Kenzo Morinaga

Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.

Skeletal removal of bisphosphonates

In certain embodiments osteoadsorptive fluorogenic substrates of cathepsin K (or other proteases) are provided. Utilizing a bisphosphonate targeting moiety, the fluorogenic substrates provide effective bone-targeted protease sensor(s). In certain embodiments the 'probes' comprise cleavable fluorophore-quencher pair linked by a cathepsin K (or other protease) peptide substrate and tethered to a bisphosphonate. Unlike existing probes that are cleared within a few days in vivo, the probes described herein (e.g., OFS-1) allow for monitoring resorption over the course of longer time periods with a single dose.

Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration

Growing community of inventors

Los Angeles, CA, United States of America

Akishige Hokugo