Nippon Shinyaku Company, Ltd.

Takara Shuzo Co., Inc.

Akiro Obayashi

Teruya Nakamura

Hiromu Murai

Osamu Tanabe

Osamu Suzuka

Masao Murayama

5-Benzy-2-pyridine carboxylic acids, in which the benzyl group is optionally substituted by one or two like or different alkyl, halo, alkoxy, nitro, amino, acetamido, hydroxy or acetoxy groups, and the corresponding amides and esters, possess dopamine .beta.-hydroxylase inhibitory properties and are useful as blood pressure lowering agents. The compounds, of which 5-(4-chlorobenzyl)-2-pyridine carboxylic acid, 5-(4-hydroxybenzyl)-2-pyridine carboxylic acid and 5-benzyl-2-pyridine carboxylic acid are typical examples, can be prepared by a number of chemical methods.

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Uji, Japan

Akiro Obayashi