Tohoku University

Kumiai Chemical Industry Co., Ltd.

National Institute of Advanced Industrial Science and Technology

Kanazawa Institute of Technology

Akira Yoshimi

Keietsu Abe

Masayuki Machida

Kiyoshi Kawai

Takashi Kubo

Tomonori Fujioka

Shigenari Yamaguchi

Maiko Umemura

Katsuya Gomi

Motoaki Sano

Ken Miyazawa

Fuka Tabata

This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of thespecies and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of thespecies.

Gene involved in synthesis of cyclic peptide compound, method for producing cyclic peptide compound using the same, and transformant comprising the same

Provided is a mutant filamentous fungus, which lacks expression of &#x3b1;-1,3-glucan, and is deficient in at least part of a GAG biosynthetic cluster. Also provided is a method of producing a substance, including the steps of: culturing the filamentous fungus to allow the filamentous fungus to produce a substance; and collecting the resulting substance.

Mutant filamentous fungus and substance production method in which said mutant filamentous fungus is used

Growing community of inventors

Sendai, Japan

Akira Yoshimi