Fujirebio Inc.

Fujizoki Pharmaceutical Co., Ltd.

Nippon Paint Compnay, Ltd.

Akira Yano

Yoshihiro Ashihara

Yasushi Kasahara

Masahisa Okada

Yoshitada Saito

Masao Oishi

Katsuaki Yoshioka

Toshiomi Nakamura

Tadashi Ninomiya

An immunoassay method using magnetic particles comprising a core and a coating layer on the surface thereof, The core comprises an organic polymer and the coating layer comprises an iron oxide type ferrite coating layer. An antigen or an antibody is bound onto the surface of the coating layer and the particle has a particle size of 0.2 to 3 .mu.m.

Immunoassay using magnetic particle

A multi-pH chemiluminescence-based assay method comprising first-stage light production by the activation by cleavage of a phosphatase cleavable dioxetane derivative within a pH range optimal for enzyme catalysis, followed by the second-stage generation of increased light energy from the products of enzyme-catalyzed cleavage of the dioxetane derivative by the adjustment of the pH to a strongly alkaline pH optimal for the generation of light energy. The assay method is suitable for both solution phase and solid state assay formats. Light generation enhancers can be used further to increase the light yield.

Chemiluminescence assays using stabilized dioxetane derivatives

A standard blood filter paper for use in diagnosis of histidinemia, comprising a piece of filter paper, and a blood material infiltrated in the above filter paper containing a known concentration of histidine and at least one salt selected from the group consisting of a dithionite, a disulfite and a bisulfite. The standard blood filter paper can be preserved for a long term at -20.degree. C.

Standard blood filter paper for use in diagnosis of histidinemia

A reference blood filter paper for measuring the concentration of methionine in the blood, comprising a piece of blood filter paper, a blood material infiltered in the blood filter paper containing a known concentration of methionine and at least one water-soluble, sulfur-containing antioxidant represented by general formula: ##STR1## where n=1 or 2.

Reference blood filter paper for measuring the concentration of

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Tokorozawa, Japan

Akira Yano