Toray Industries, Inc.

Akira Yanai

Masahiro Satoh

Susumu Matsuda

Toru Sakurai

Yoshizumi Ueda

Naoko Nakamura

Katsushige Yamada

Fumiyoshi Okano

Masatoshi Watanabe

Saburo Sone

Akemi Kajita

Eiji Sato

Naomi Hara

A method for inhibiting cell growth is provided. The method includes the step of systemically administering a pharmaceutical preparation containing an interferon as an active ingredient two or more times a day, and is specifically useful for cancer treatment.

Method for inhibiting brain tumor or colon carcinoma

A method of stabilizing a useful protein by mixing a useful protein and an aqueous solution of a compound having the basic structure of arabic acid, and a stabilizied useful protein compositon containing a useful protein and a compound having the basic structure of arabic acid; gum arabic is preferred as a compound having the basic structure of arabic acid, and examples of a useful protein include cytokine and interferon; and a production method for canine interferon-&ggr; and stabilization thereof.

Method of stabilizing useful protein and useful protein compositions

A synthetic plasmid in which DNA encoding protein of a feline interferon is integrated, a transformant obtainable by the transformation of a host cell by the use of the synthetic plasmid and a feline interferon having a biological activity given by a protein carrying a specific amino acid sequence, a feline interferon gene encoding the feline interferon, a feline interferon precursor comprised of a cleavable peptide or a signal peptide being linked to the N terminal of the feline interferon, a feline interferon precursor gene encoding the feline interferon precursor and a method for producing the feline interferon, which are applied to the mass production of a feline interferon to be used as a remedy for feline viral disease and tumor.

Synthetic plasmids and transformants comprising a feline interferon cDNA

Purified feline interferon polypeptides are disclosed. A synthetic plasmid in which DNA encoding protein of a feline interferon is integrated, a transformant obtainable by the transformation of a host cell by the use of the synthetic plasmid and a feline interferon having a biological activity given by a protein carrying a specific amino acid sequence, a feline interferon gene encoding the feline interferon, a feline interferon precursor comprised of a cleavable peptide or a signal peptide being linked to the N terminal of the feline interferon, a feline interferon precursor gene encoding the feline interferon precursor and a method for producing the feline interferon, which are applied to the mass production of a feline interferon to be used as a remedy for feline vital disease and tumor.

Feline interferon

A recombinant silkworm nuclear polyhedrosis virus containing DNA coding for a protein of feline interferon; the recombinant virus is constructed by cotransfection a recombinant plasmid having a gene coding for a protein of feline interferon and a silkworm nuclear polyhedrosis virus DNA into established silkworm cells, and cloning the desired recombinant virus. The recombinant virus is useful for a mass-production of feline interferon.

Feline interferon and process for production thereof

Dextro or d-tartaric acid is prepared by microbial conversion of cis-epoxysuccinic acid which is subjected to asymmetrical hydrolysis by the catalytic action of a microorganism taken from the group consisting of the genera Achromobacter and Alcaligenes in which cis-epoxysuccinic acid in an aqueous solution is brought into contact with the enzyme d-tartrate epoxidase.

Growing community of inventors

Kamakura, Japan

Akira Yanai