Iolab Corporation

Nihon Medi-physics Company, Limited

Ciba Vision Corporation

Chiron Vision Corporation

Akira Yamada

Namassivaya Doddi

Charles D Beard

Gary B Dunks

Teresa H Kuan

Akira Yokoyama

Yasushi Arano

Moises A Valle

Hisashi Tanaka

Oh-Seung Kwon

Robert James Kellar

Andrea Borgelt

Ajay Vasudev Pandurangi

A method of processing a soft or foldable lens includes a step of tumbling (grinding) the lens in a tumbling medium. The tumbling medium includes a mixture of glass beads coated with an abrasive material, alcohol and water. This process applies to single piece and multipiece soft lenses.

Intraocular lens tumbling process using coated beads

A package containing an aqueous drug composition containing an insoluble resin comprising benzalkonium salt units in an amount sufficient to inhibit growth of microbes in said aqueous drug solution. Typically, the insoluble resin is a polymer having repeating units of the formula:

Poly(benzalkonium salt) as an anti-microbial agent for aqueous drug

Composite acrylic polymer rods having clear central regions and colored peripheral regions are prepared by polymerizing a flowable solution comprising acrylic monomer, dye and, dissolved therein, acrylic polymer, around a rod of acrylic polymer. Alternatively, a rod of acrylic polymer surrounded by a flowable mixture comprising partially polymerized acrylic monomer and dye is subjected to polymerization conditions to polymerize the flowable mixture.

Method of preparing composite single-piece intraocular lenses with

Vinylsilylalkoxy arylbenzotriazol monomers such as 2-[3'-t-butyl-5'-(3-'-dimethylvinylsilylpropoxy)-2'-hydroxy-phenyl]-5-meth oxybenzotriazole are disclosed. These monomers can be incorporated in optically clear silicone polymers to form intraocular lenses, contact lenses, and the like, which have UV absorbing properties.

Vinylsilylalkoxy arylbenzotriazole compounds and UV absorbing

Ultraviolet light absorbing compositions comprising 2-(2'-hydroxy-5'-acryloyloxyalkoxyphenyl(-2H-benzotrizoles, and copolymers thereof with one or more other monomers copolyermizable therewith, particularly acrylic monomers, are useful in the manufacture of ocular devices, particularly intraocular lenses and contact lenses.

Ultraviolet absorbing polymers comprising

The compounds 2'-hydroxy-5'-(hydroxyalkyl)phenyl-2H-benzotriazoles are useful as intermediate alcohols in the preparation of corresponding 2'-hydroxy-5'-acrylyloxyphenyl-2H-benzotriazole monomers, which in turn are copolymerizable with ethylenically unsaturated monomers, particularly acrylic monomers, to impart ultraviolet absorbing properties to the resulting copolymers.

2'-hydroxy-5'-(hydroxyalkyl)phenyl-2H-benzotriazoles

Ultraviolet light absorbing polymer compositions comprising copolymers of 2-Hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles with one or more other monomers copolymerizable therewith, particularly acrylic monomers are useful in the manufacture of occular devices, particularly intraoccular lenses and contact lenses. Polymers of the disclosed benzotriazoles may be added to other organic materials to impart ultraviolet absorbing properties thereo.

A radioactive diagnostic agent for imaging of various organs, particularly of brain, which comprises a radioactive element such as .sup.99m TC and a non-radioactive carrier comprising as the essential component glucosone-bis(thiosemecarbazone) of the formula: ##STR1##

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Claremont, CA, United States of America

Akira Yamada