Kotobuki Seiyaku Co. Ltd.

Kotobuki Pharmaceutical Co Ltd

Akira Tomiyama

Tsuyoshi Tomiyama

Naoto Ueyama

Takashi Yanagisawa

Motoharu Sonegawa

Koichi Kubota

Tomoyuki Kawai

Shuuichi Wakabayashi

Masayuki Yokota

Atsushi Noda

Hiroshi Tomiyama

Akira Ohno

Tadashi Shirai

Masafumi Yasunami

Hiromi Baba

Kahei Takase

Shuichi Wakabayshi

Junko Sekiguchi

Hironao Sajiki

Takeyuki Imamaki

Satoru Takeuchi

Rei Koyama

Hiromi Hayashi

Keiko Kuroiwa

Makoto Haketa

Satoko Uchibori

C-glycosides and preparation of thereof as antidiabetic agents

Ether and amide compounds preparation thereof composition containing same and use thereof as antidiadetics

A method for preparation of a cycloheptimidazole compound having formula (5),

Method for preparing cycloheptimidazoles

The present invention relates to compounds of formula (1).

3-Substituted-2-halocycloheptenone compounds and a method for manufacturing same

New therapeutic agents of isoquinuclidine derivatives are represented by the following formula or its hydrochloride salts. ##STR1## (wherein R.sub.1 is hydrogen, carboxyl group, ethoxycarbonyl group, 4-(ethoxycarbonyl)phenyl group, 4-(carboxy)phenyl group, 2-(carboxy)-thiophene-5-yl group, quinoline-5-yl group, 4-(quinoline-5-yl)phenyl group or 4-(3-oxo-2-azabicyclo[2.2.2]octane-2-yl)-phenyl group; R.sub.2 is hydrogen or allyl group; Both X.sub.1 and X.sub.2 are hydrogen and X.sub.1 and X.sub.2 may form an oxo group; m stands for an integer of 0 to 2.) These compounds, have excellent inhibitory activities against squalene synthase, and are useful as a treatment agent for hypercholesterolemia.

Isoquinuclidine derivatives, method of manufacturing the same and

New therapeutic agents of carboxylic acid derivatives are disclosed, which are represented by the compounds of the following formula (I) or its pharmaceutically acceptable salts, ##STR1## These compounds are useful as a matrix metalloproteinases (MMPs) inhibitors.

Carboxylic acid derivatives, method of manufacturing the same and

A series of new azulene derivatives are disclosed, which are represented by the following formula; ##STR1## wherein: R.sub.1 is hydrogen atom, lower alkoxycarbonyl group, carboxy group, halogen atom, lower alkyl group, phenyl group or lower alkanoyl group; R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom, lower alkyl group, lower alkoxy group or halogen atom; X is lower alkyl group or amino group. The compounds of the present invention are useful for treatment of inflammation.

2-phenylazulene derivatives and a manufacturing method of these compounds

New therapeutic agent of carboxymethylidenecycloheptimidazole derivatives and method for the manufacture thereof are disclosed, which are represented by the following formula or its alkali addition salts ##STR1## (wherein R.sub.1 represents a lower alkyl; R.sub.2 represents H or isopropyl group; R.sub.3 represent H, a lower alkyl or --C(CH.sub.3)H--OCOOR.sub.4 (R.sub.4 is a lower alkyl or cyclohexyl) and .dbd.CHCOOR.sub.3 is substituted group at 4 or 8 position; A represents ##STR2## These compounds are useful as anti-hypertensive, anti-congestive heart failure agents and intraocular pressure lowering agents.

Carboxymethylidenecycloheptimidazole derivatives, method of

New therapeutic agents of cycloheptimidazole derivatives are disclosed, which are represented by the following formula or its alkali-addition salts. ##STR1## (wherein R.sub.1 represents H or isopropyl group; R.sub.2 represents a lower alkyl; R.sub.3 represents a carboxylic acid or tetrazole group. A and A.sub.1 are substituted groups at 4 or 8 position and A.sub.1 is a hydrogen or hydroxy group when A is a hydrogen or A and A.sub.1 is an oxo group. The dotted line '- - - -' is two double bonds or saturated single bonds). These compounds are useful as anti-hypertensive or anti-congestive heart failure agents.

Cycloheptimidazole derivatives, method of manufacturing the same and

A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic acid derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

Benzofuran and benzothiophene derivatives, anti-hyperuricemia agents

Derivatives of cyclic guanidine are disclosed, which are represented by the following formula:

Cyclic guanidine derivatives, anti-ulceratives and method of

A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic adic derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

Benzothiophene derivatives and antihyperuricemia thereof

A series of new azulene analogues are disclosed, which are represented by the following formula: ##STR1## wherein: R.sub.1 is --COOH, --COOR.sub.4 (R.sub.4 represents a lower alkyl), --CH.dbd.CH--COOH, --CH.sub.2 --COOH or --SO.sub.3 H;

Growing community of inventors

Sakaki, Japan

Akira Tomiyama