Kyowa Hakko Kogyo Co., Ltd.

Other

Kyowa Hakko Kirin Co., Limited

Akira Togayachi

Katsutoshi Sasaki

Hisashi Narimatsu

Satoshi Nakagawa

Susumu Sekine

Ayumi Natsume

Hiroyuki Mio

Soichiro Isshiki

The present invention provides a novel polypeptide having a &#x3b2;1,3-N-acetylglucosaminyltransferase activity, an agent for synthesizing a sugar chain comprising the polypeptide, a process for producing a sugar chain or a complex carbohydrate using the agent for synthesizing a sugar chain, DNA encoding the polypeptide, a process for producing the polypeptide, an antibody against the polypeptide, and a diagnosis method and a medicament for treatment for inflammation, cancer or tumor metastasis using the DNA or the antibody. The present invention is useful for synthesis of a useful sugar chain and diagnosis and treatment for inflammatory diseases, cancer or tumor metastasis.

Transformed cell harboring DNA or RNA encoding sugar chain synthesizing agent having &#x3b2;1,3-N-acetylglucosaminyltransferase activity

Process for producing sugar chains using &#x3b2;1,3-N-acetylglucosaminyltransferase

According to the present invention, there can be provided a novel polypeptide having &#x3b2;1,3-galactosyltransferase activity involved in the synthesis of type 1 sugar chains, a DNA coding for said polypeptide, a recombinant vector comprising said DNA, a transformant carrying said recombinant vector, a process for producing type 1 sugar chain-containing sugar chains and complex carbohydrates by use of said polypeptide or said transformant, an antibody recognizing said polypeptide, a method for detecting or quantifying said polypeptide by use of said antibody, a method for screening a substance correlated with said polypeptide, a method for diagnosis or treatment of cancers in the digestive system by use of said DNA or said antibody, and a method for treatment of cancers in the digestive system by use of a substance obtained by said screening method.

Polypeptide

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Higashikurume, Japan

Akira Togayachi