Seikagaku Corporation

Akira Tawada

Akira Asari

Keiichi Yoshida

Yuji Matsuzaki

Satoshi Miyauchi

Hitoshi Kurihara

Yuka Miyazaki

Hiroko Yamanokuchi

Takahiro Masa

Tomomi Shibata

Hiroshi Maruyama

Kiyoshi Morikawa

Hideo Mochizuki

Masami Iida

Junichi Onaya

Yousuke Yasuda

Yusuke Hori

A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.

Hyaluronic acid oligosaccharide fractions and drugs containing the same

Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.

Method for producing oligosaccharide, and novel oligosaccharide and pharmaceutical composition containing the same

Lactosamine oligosaccharide and method for producing the same

A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at least disaccharide represented by the formula Gal(6S)-GlcNAc(6S) (in the formula, Gal, GlcN, Ac, and 6S represent a galactose, a glucosamine, an acetyl group, and a 6-O-sulfate ester, respectively) as a constitutional ingredient, and/or pharmaceutically acceptable salt thereof are used as active ingredients of anti-inflammatory agents, antiallergic agents, immunomodulators, cell differentiation inducers, and apoptosis inducers.

Keratan sulfate oligosaccharide fraction and pharmaceutical containing

Lactosamine oligosaccharides and method for producing the same

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Saitama, Japan

Akira Tawada