Ube Industries, Inc.

Chugai Seiyaku Kabushiki Kaisha

Sanwa Kagaku Kenkyusho Co., Ltd.

Akira Takama

Kikuo Ataka

Hiroyuki Miyata

Yasuhito Yamamoto

Yasunori Tsuzaki

Masahiko Hagihara

Ken-ichi Komori

Kazutaka Kido

Hiroshi Nishida

Hidetoshi Sunamoto

Takeshi Matsugi

Ryo Iwamura

Masayoshi Oku

Hiroyuki Setoguchi

Hiroto Akaza

Yuka Kuno

Tomokazu Fujimoto

Kazuma Sakata

Tatsuya Kawaguchi

Hiroyuki Suenaga

Ken-Ichi Komori

Disclosed herein are a crystal comprising a compound, which has &#x3bc;-opioid receptor antagonistic action, few side effects, and high safety, and having high purity and excellent physical properties (stability, solubility, etc.), and a method for producing the crystal. The crystal is a crystal of a salt comprising: a compound represented by a formula (I) [wherein Ris a hydrogen atom or a halogen atom, and Ris a group selected from the group consisting of and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, and oxalic acid, or a hydrate thereof.

Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof

A compound represented by formula (1) or salt thereof and a production intermediate thereof are created. The compound exhibited an excellent antioxidation action in a microsome lipid peroxidation measuring system using a rat liver microsome. Therefore, the compound or salt thereof is useful as an antioxidant. The present invention also provides use of a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof for production of an antioxidant. 

Indazole derivative or salt thereof and production intermediate thereof, and antioxidant using same, and use of indazole derivative or salt thereof

The present invention is to provide a process for producing a 2'-O-acetyl-4&#x2033;-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin compound which comprises reacting a formylating agent with a 2&#x2032;-O-acetylerythromycin A compound 2 to obtain 2-&#x2032;-O-acetyl-4&#x2033;-O-formylerythromycin A compound 3, then, acting an acid on Compound 3 to subject to hemiketalation, and then adding an aqueous basic solution in an aqueous solution to precipitate Compound 4 as free crystals.

Process for preparing erythromycin compound

The present invention is to provide a process for producing a 2'-O-acetyl-4&#x2033;-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound, and it provide a process for producing an erythromycin compound which comprises reacting a formylating agent with a 2&#x2032;-O-acetylerythromycin A compoundto obtain 2&#x2032;-O-acetyl-4&#x2033;-O-formylerythromycin A compound, then, acting an acid on Compoundto subject to hemiketalation, and then adding an aqueous basic solution in an aqueous solution to precipitate Compoundas free crystals.

Process for preparation of erythromycin compounds

13-membered ring macrolide compound, medicine containing the same, and

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Ube, Japan

Akira Takama